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• W2046232210 abstract "The GluN2B (GluRε2/NR2B) and GluN2A (GluRε1/NR2A) NMDA receptor (NMDAR) subtypes have been differentially implicated in activity-dependent synaptic plasticity. However, little is known about the respective contributions made by these two subtypes to developmental plasticity, in part because studies of GluN2B KO [ Grin2b −/− ( 2b −/− )] mice are hampered by early neonatal mortality. We previously used in vitro slice cocultures of rodent cerebral cortex (Cx) and spinal cord (SpC) to show that corticospinal (CS) synapses, once present throughout the SpC, are eliminated from the ventral side during development in an NMDAR-dependent manner. To study subtype specificity of NMDAR in this developmental plasticity, we cocultured Cx and SpC slices derived from postnatal day 0 (P0) animals with different genotypes [ 2b −/− , Grin2a −/− ( 2a −/− ), or WT mice]. The distribution of CS synapses was studied electrophysiologically and with a voltage-sensitive dye. Synapse elimination on the ventral side was blocked in WT(Cx)- 2b −/− (SpC) pairs but not in WT(Cx)- 2a −/− (SpC) or 2b −/− (Cx)-WT(SpC) pairs. CS axonal regression was also observed through live imaging of CS axons labeled with enhanced yellow fluorescent protein (EYFP) through exo utero electroporation. These findings suggest that postsynaptic GluN2B is selectively involved in CS synapse elimination. In addition, the elimination was not blocked in 2a −/− SpC slices, where Ca 2+ entry through GluN2B-mediated CS synaptic currents was reduced to the same level as in 2b −/− slices, suggesting that the differential effect of GluN2B and GluN2A in CS synapse elimination might not be explained based solely on greater Ca 2+ entry through GluN2B-containing channels." @default.
• W2046232210 created "2016-06-24" @default.
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• W2046232210 date "2010-08-09" @default.
• W2046232210 modified "2023-10-14" @default.
• W2046232210 title "Specific involvement of postsynaptic GluN2B-containing NMDA receptors in the developmental elimination of corticospinal synapses" @default.
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• W2046232210 doi "https://doi.org/10.1073/pnas.0906551107" @default.
• W2046232210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2930522" @default.
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