FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046234296> ?p ?o ?g. }

• W2046234296 endingPage "761" @default.
• W2046234296 startingPage "748" @default.
• W2046234296 abstract "OBJECTIVES: Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective antimigration therapies have been developed. This study investigated the effect of infliximab therapy on the mucosal gene expression of CAMs in IBD. METHODS: Mucosal gene expression of 69 leukocyte/endothelial CAMs and E-cadherin was investigated in 61 IBD patients before and after first infliximab infusion and in 12 normal controls, using Affymetrix gene expression microarrays. Quantitative reverse transcriptase-PCR (qRT-PCR), immunohistochemistry, and western blotting were used to confirm the microarray data. RESULTS: When compared with control colons, the colonic mucosal gene expression of most leukocyte/endothelial adhesion molecules was upregulated and E-cadherin gene expression was downregulated in active colonic IBD (IBDc) before therapy, with no significant colonic gene expression differences between ulcerative colitis and colonic Crohn's disease. Infliximab therapy restored the upregulations of leukocyte CAMs in IBDc responders to infliximab that paralleled the disappearance of the inflammatory cells from the colonic lamina propria. Also, the colonic gene expression of endothelial CAMs and of most chemokines/chemokine receptors returned to normal after therapy in IBDc responders, and onlyCCL20andCXCL1-2expression remained increased after therapy in IBDc responders vs. control colons. When compared with control ileums, the ileal gene expression ofMADCAM1,THY1,PECAM1,CCL28,CXCL1,-2,-5, -6, and -11,andIL8was increased andCD58expression was decreased in active ileal Crohn's disease (CDi) before therapy, and none of the genes remained dysregulated after therapy in CDi responders vs. control ileums. This microarray study identified a number of interesting targets for antiadhesion therapy including PECAM1, IL8, and CCL20, besides the currently studied α4β7 integrin–MADCAM1 axis. CONCLUSIONS: Our data demonstrate that many leukocyte/endothelial CAMs and chemokines/chemokine receptors are upregulated in inflamed IBD mucosa. Controlling the inflammation with infliximab restores most of these dysregulations in IBD. These results show that at least part of the mechanism of anti-tumor necrosis factor-α therapy goes through downregulation of certain adhesion molecules." @default.
• W2046234296 created "2016-06-24" @default.
• W2046234296 creator A5003632939 @default.
• W2046234296 creator A5003855551 @default.
• W2046234296 creator A5004944979 @default.
• W2046234296 creator A5005701700 @default.
• W2046234296 creator A5016495724 @default.
• W2046234296 creator A5019474609 @default.
• W2046234296 creator A5032417574 @default.
• W2046234296 creator A5045465014 @default.
• W2046234296 creator A5051714890 @default.
• W2046234296 creator A5066952822 @default.
• W2046234296 creator A5071139769 @default.
• W2046234296 creator A5085128448 @default.
• W2046234296 date "2011-04-01" @default.
• W2046234296 modified "2023-10-18" @default.
• W2046234296 title "Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment" @default.
• W2046234296 cites W1519962349 @default.
• W2046234296 cites W1972755311 @default.
• W2046234296 cites W1973606162 @default.
• W2046234296 cites W1978475974 @default.
• W2046234296 cites W1989108502 @default.
• W2046234296 cites W1995864039 @default.
• W2046234296 cites W1997702183 @default.
• W2046234296 cites W2053303708 @default.
• W2046234296 cites W2062626858 @default.
• W2046234296 cites W2070092476 @default.
• W2046234296 cites W2074246451 @default.
• W2046234296 cites W2081098333 @default.
• W2046234296 cites W2085430804 @default.
• W2046234296 cites W2093566767 @default.
• W2046234296 cites W2103588593 @default.
• W2046234296 cites W2108244474 @default.
• W2046234296 cites W2110072677 @default.
• W2046234296 cites W2116318925 @default.
• W2046234296 cites W2120179781 @default.
• W2046234296 cites W2123934318 @default.
• W2046234296 cites W2141753081 @default.
• W2046234296 cites W2145245891 @default.
• W2046234296 cites W2160697532 @default.
• W2046234296 cites W2170989872 @default.
• W2046234296 cites W2171297959 @default.
• W2046234296 cites W2328126238 @default.
• W2046234296 cites W4231449157 @default.
• W2046234296 doi "https://doi.org/10.1038/ajg.2011.27" @default.
• W2046234296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21326222" @default.
• W2046234296 hasPublicationYear "2011" @default.
• W2046234296 type Work @default.
• W2046234296 sameAs 2046234296 @default.
• W2046234296 citedByCount "119" @default.
• W2046234296 countsByYear W20462342962012 @default.
• W2046234296 countsByYear W20462342962013 @default.
• W2046234296 countsByYear W20462342962014 @default.
• W2046234296 countsByYear W20462342962015 @default.
• W2046234296 countsByYear W20462342962016 @default.
• W2046234296 countsByYear W20462342962017 @default.
• W2046234296 countsByYear W20462342962018 @default.
• W2046234296 countsByYear W20462342962019 @default.
• W2046234296 countsByYear W20462342962020 @default.
• W2046234296 countsByYear W20462342962021 @default.
• W2046234296 countsByYear W20462342962022 @default.
• W2046234296 countsByYear W20462342962023 @default.
• W2046234296 crossrefType "journal-article" @default.
• W2046234296 hasAuthorship W2046234296A5003632939 @default.
• W2046234296 hasAuthorship W2046234296A5003855551 @default.
• W2046234296 hasAuthorship W2046234296A5004944979 @default.
• W2046234296 hasAuthorship W2046234296A5005701700 @default.
• W2046234296 hasAuthorship W2046234296A5016495724 @default.
• W2046234296 hasAuthorship W2046234296A5019474609 @default.
• W2046234296 hasAuthorship W2046234296A5032417574 @default.
• W2046234296 hasAuthorship W2046234296A5045465014 @default.
• W2046234296 hasAuthorship W2046234296A5051714890 @default.
• W2046234296 hasAuthorship W2046234296A5066952822 @default.
• W2046234296 hasAuthorship W2046234296A5071139769 @default.
• W2046234296 hasAuthorship W2046234296A5085128448 @default.
• W2046234296 hasConcept C104317684 @default.
• W2046234296 hasConcept C13373296 @default.
• W2046234296 hasConcept C142724271 @default.
• W2046234296 hasConcept C150194340 @default.
• W2046234296 hasConcept C16224149 @default.
• W2046234296 hasConcept C17991360 @default.
• W2046234296 hasConcept C203014093 @default.
• W2046234296 hasConcept C2775862500 @default.
• W2046234296 hasConcept C2776914184 @default.
• W2046234296 hasConcept C2777138892 @default.
• W2046234296 hasConcept C2777310793 @default.
• W2046234296 hasConcept C2778260677 @default.
• W2046234296 hasConcept C2779134260 @default.
• W2046234296 hasConcept C2780479503 @default.
• W2046234296 hasConcept C529295009 @default.
• W2046234296 hasConcept C55493867 @default.
• W2046234296 hasConcept C71924100 @default.
• W2046234296 hasConcept C86803240 @default.
• W2046234296 hasConcept C96525457 @default.
• W2046234296 hasConceptScore W2046234296C104317684 @default.
• W2046234296 hasConceptScore W2046234296C13373296 @default.
• W2046234296 hasConceptScore W2046234296C142724271 @default.
• W2046234296 hasConceptScore W2046234296C150194340 @default.

• next