FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046236013> ?p ?o ?g. }

• W2046236013 endingPage "436" @default.
• W2046236013 startingPage "433" @default.
• W2046236013 abstract "Ketotifen is an oral antiallergic drug developed in 1970 by Sandoz Pharmaceuticals of Switzerland. It is a benzocycloheptathiophene derivative and was initially marketed as an inhibitor of anaphylaxis. [1] Kamide R. Niimura M. Ueda H. et al. Clinical evaluation of ketotifen for chronic urticaria: multicenter double-blind comparative study with clemastine. Ann Allergy. 1989; 62: 322-325 PubMed Google Scholar The pharmacodynamic properties of ketotifen are many, because it is an inhibitor of the release and/or activity of mast cell and basophil mediators, including histamine, neutrophil, and eosinophil chemotactic factors, arachidonic acid metabolites, prostaglandins, and leukotrienes. [2] St-Pierre J.P. Kobric M. Rackham A. Effect of ketotifen treatment on cold-induced urticaria. Ann Allergy. 1985; 55: 840-843 PubMed Google Scholar Thus, it inhibits the bronchial response to inhaled histamine, allergen, or aspirin. In addition, the ocular, nasal, and dermal responses to applied allergen in sensitized patients are attenuated with use of ketotifen. [3] Grant S.M. Goa K.L. Fitton A. Sorkin E.M. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs. 1990; 40: 412-448 Crossref PubMed Scopus (192) Google Scholar It also has been found to have some calcium antagonist activity and to inhibit responses to platelet-activating factor from proinflammatory cells, such as eosinophils. [2] St-Pierre J.P. Kobric M. Rackham A. Effect of ketotifen treatment on cold-induced urticaria. Ann Allergy. 1985; 55: 840-843 PubMed Google Scholar Additional possible modes of action include its ability to reverse β2-agonist–induced decreases in β-adrenoreceptor density and to alter the affinity of these receptors and increase intracellular concentrations of cyclic adenosine monophosphate. [3] Grant S.M. Goa K.L. Fitton A. Sorkin E.M. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs. 1990; 40: 412-448 Crossref PubMed Scopus (192) Google Scholar Ketotifen has a chemical structure similar to some first-generation antihistamines, such as cyproheptadine and azatidene. [2] St-Pierre J.P. Kobric M. Rackham A. Effect of ketotifen treatment on cold-induced urticaria. Ann Allergy. 1985; 55: 840-843 PubMed Google Scholar With regard to the pharmacokinetic properties of ketotifen, it is readily absorbed from the gastrointestinal tract after oral administration and achieves peak plasma concentrations within 2 to 4 hours of administration. Clearance of the drug from plasma is biphasic, with a half-life of distribution of 3 hours and a half-life of elimination of 22 hours in adults. [3] Grant S.M. Goa K.L. Fitton A. Sorkin E.M. Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders. Drugs. 1990; 40: 412-448 Crossref PubMed Scopus (192) Google Scholar However, the onset of action of ketotifen is slow, and it may take 4 to 6 weeks to achieve full prophylactic value under certain conditions. [4] Karaayvaz M. Calişkaner Z. Turan M. Akar A. Oztürk S. Ozangüç N. Levothyroxine versus ketotifen in the treatment of patients with chronic urticaria and thyroid autoimmunity. J Dermatol Treat. 2002; 13: 165-172 Crossref PubMed Scopus (10) Google Scholar" @default.
• W2046236013 created "2016-06-24" @default.
• W2046236013 creator A5015277641 @default.
• W2046236013 creator A5034842495 @default.
• W2046236013 creator A5056949003 @default.
• W2046236013 creator A5090629949 @default.
• W2046236013 date "2013-12-01" @default.
• W2046236013 modified "2023-09-26" @default.
• W2046236013 title "Ketotifen in the management of chronic urticaria: resurrection of an old drug" @default.
• W2046236013 cites W1986048225 @default.
• W2046236013 cites W2001724482 @default.
• W2046236013 cites W2031576513 @default.
• W2046236013 cites W2056737105 @default.
• W2046236013 cites W2062353909 @default.
• W2046236013 cites W2068687597 @default.
• W2046236013 cites W2076748965 @default.
• W2046236013 cites W2091277991 @default.
• W2046236013 cites W2111622263 @default.
• W2046236013 doi "https://doi.org/10.1016/j.anai.2013.10.003" @default.
• W2046236013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309375" @default.
• W2046236013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24267353" @default.
• W2046236013 hasPublicationYear "2013" @default.
• W2046236013 type Work @default.
• W2046236013 sameAs 2046236013 @default.
• W2046236013 citedByCount "25" @default.
• W2046236013 countsByYear W20462360132013 @default.
• W2046236013 countsByYear W20462360132015 @default.
• W2046236013 countsByYear W20462360132016 @default.
• W2046236013 countsByYear W20462360132017 @default.
• W2046236013 countsByYear W20462360132018 @default.
• W2046236013 countsByYear W20462360132019 @default.
• W2046236013 countsByYear W20462360132020 @default.
• W2046236013 countsByYear W20462360132021 @default.
• W2046236013 countsByYear W20462360132022 @default.
• W2046236013 countsByYear W20462360132023 @default.
• W2046236013 crossrefType "journal-article" @default.
• W2046236013 hasAuthorship W2046236013A5015277641 @default.
• W2046236013 hasAuthorship W2046236013A5034842495 @default.
• W2046236013 hasAuthorship W2046236013A5056949003 @default.
• W2046236013 hasAuthorship W2046236013A5090629949 @default.
• W2046236013 hasBestOaLocation W20462360132 @default.
• W2046236013 hasConcept C1122143 @default.
• W2046236013 hasConcept C203014093 @default.
• W2046236013 hasConcept C207480886 @default.
• W2046236013 hasConcept C2775933838 @default.
• W2046236013 hasConcept C2776042228 @default.
• W2046236013 hasConcept C2780571441 @default.
• W2046236013 hasConcept C2780870513 @default.
• W2046236013 hasConcept C71924100 @default.
• W2046236013 hasConcept C98274493 @default.
• W2046236013 hasConceptScore W2046236013C1122143 @default.
• W2046236013 hasConceptScore W2046236013C203014093 @default.
• W2046236013 hasConceptScore W2046236013C207480886 @default.
• W2046236013 hasConceptScore W2046236013C2775933838 @default.
• W2046236013 hasConceptScore W2046236013C2776042228 @default.
• W2046236013 hasConceptScore W2046236013C2780571441 @default.
• W2046236013 hasConceptScore W2046236013C2780870513 @default.
• W2046236013 hasConceptScore W2046236013C71924100 @default.
• W2046236013 hasConceptScore W2046236013C98274493 @default.
• W2046236013 hasIssue "6" @default.
• W2046236013 hasLocation W20462360131 @default.
• W2046236013 hasLocation W20462360132 @default.
• W2046236013 hasLocation W20462360133 @default.
• W2046236013 hasLocation W20462360134 @default.
• W2046236013 hasOpenAccess W2046236013 @default.
• W2046236013 hasPrimaryLocation W20462360131 @default.
• W2046236013 hasRelatedWork W1967213352 @default.
• W2046236013 hasRelatedWork W1971949671 @default.
• W2046236013 hasRelatedWork W1978957978 @default.
• W2046236013 hasRelatedWork W1995352571 @default.
• W2046236013 hasRelatedWork W2008636872 @default.
• W2046236013 hasRelatedWork W2018254719 @default.
• W2046236013 hasRelatedWork W2105970215 @default.
• W2046236013 hasRelatedWork W2321494368 @default.
• W2046236013 hasRelatedWork W2413223805 @default.
• W2046236013 hasRelatedWork W2992710416 @default.
• W2046236013 hasVolume "111" @default.
• W2046236013 isParatext "false" @default.
• W2046236013 isRetracted "false" @default.
• W2046236013 magId "2046236013" @default.
• W2046236013 workType "article" @default.