FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046236305> ?p ?o ?g. }

• W2046236305 abstract "The differential feedback actions of estrogen (E2) on gonadotropin secretion were studied by means of an in vivo isolated pituitary paradigm. Adult female rats were hypophysectomized (hypox) and the next day received single anterior pituitary transplants (graft) under the kidney capsule. At the same time rats underwent bilateral ovariectomy. On the third day each animal was fitted with a catheter system which allowed for intermittent infusions of LHRH (250 ng/5 min.h) and chronic blood sampling. Rats received LHRH infusions for 7 days. On the sixth day of LHRH infusions blood samples were collected for 4 h 5, 15, 25, 35, 45 min after each hourly LHRH pulse. After 1 h of sampling, animals received sc injections of 2 micrograms estradiol benzoate (EB; n = 5) or oil vehicle (n = 5). Plasma LH, FSH, E2, and PRL levels in samples from all groups were determined by RIA. In hypox/graft rats LH release, but not FSH release, was pulsatile in response to the hourly LHRH infusions. Injection of EB in the hypox/graft rats significantly (P less than 0.05) suppressed LH release within 3 h by 57%, while FSH was unaffected. PRL levels were elevated by approximately 10-fold in the hypox/graft animals compared to those in pituitary-intact rats. These levels, however, were not changed as a function of steroid treatment and, therefore, could not account for the effects of EB on LH secretion. On the basis of these observations we conclude that 1) a major inhibitory effect of an acute injection of EB on LH secretion is exerted by a direct action on pituitary gonadotropes, and 2) E2 can differentially affect the release of LH and FSH by an intrapituitary mechanism. It is hoped that development of this model will allow for further investigation of the cellular mechanisms that mediate feedback actions of E2 on pituitary gonadotropes exposed to intermittent LHRH stimulation." @default.
• W2046236305 created "2016-06-24" @default.
• W2046236305 creator A5014769599 @default.
• W2046236305 creator A5025559638 @default.
• W2046236305 date "1988-07-01" @default.
• W2046236305 modified "2023-09-26" @default.
• W2046236305 title "Estrogen Inhibits Luteinizing Hormone (LH), but Not Follicle-Stimulating Hormone Secretion in Hypophysectomized Pituitary-Grafted Rats Receiving Pulsatile LH-Releasing Hormone Infusions*" @default.
• W2046236305 cites W1421132695 @default.
• W2046236305 cites W1868088927 @default.
• W2046236305 cites W1963726044 @default.
• W2046236305 cites W1968853284 @default.
• W2046236305 cites W1969085914 @default.
• W2046236305 cites W1976414769 @default.
• W2046236305 cites W1978308275 @default.
• W2046236305 cites W2008733524 @default.
• W2046236305 cites W2021189800 @default.
• W2046236305 cites W2024451669 @default.
• W2046236305 cites W2024735389 @default.
• W2046236305 cites W2034286317 @default.
• W2046236305 cites W2041122938 @default.
• W2046236305 cites W2044601133 @default.
• W2046236305 cites W2050263686 @default.
• W2046236305 cites W2054751732 @default.
• W2046236305 cites W2055240421 @default.
• W2046236305 cites W2056851475 @default.
• W2046236305 cites W2059011677 @default.
• W2046236305 cites W2059592013 @default.
• W2046236305 cites W2067713504 @default.
• W2046236305 cites W2069657152 @default.
• W2046236305 cites W2070625108 @default.
• W2046236305 cites W2071158665 @default.
• W2046236305 cites W2071599591 @default.
• W2046236305 cites W2072065279 @default.
• W2046236305 cites W2075100913 @default.
• W2046236305 cites W2075442956 @default.
• W2046236305 cites W2089668370 @default.
• W2046236305 cites W2091553801 @default.
• W2046236305 cites W2092486725 @default.
• W2046236305 cites W2095578937 @default.
• W2046236305 cites W2108819835 @default.
• W2046236305 cites W2115183998 @default.
• W2046236305 cites W2122661845 @default.
• W2046236305 cites W2124082367 @default.
• W2046236305 cites W2130134811 @default.
• W2046236305 cites W2146853018 @default.
• W2046236305 cites W2146900772 @default.
• W2046236305 cites W2158778657 @default.
• W2046236305 cites W2163754824 @default.
• W2046236305 cites W2168691742 @default.
• W2046236305 cites W2313150759 @default.
• W2046236305 doi "https://doi.org/10.1210/endo-123-1-622" @default.
• W2046236305 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3133202" @default.
• W2046236305 hasPublicationYear "1988" @default.
• W2046236305 type Work @default.
• W2046236305 sameAs 2046236305 @default.
• W2046236305 citedByCount "40" @default.
• W2046236305 countsByYear W20462363052015 @default.
• W2046236305 countsByYear W20462363052016 @default.
• W2046236305 countsByYear W20462363052020 @default.
• W2046236305 crossrefType "journal-article" @default.
• W2046236305 hasAuthorship W2046236305A5014769599 @default.
• W2046236305 hasAuthorship W2046236305A5025559638 @default.
• W2046236305 hasConcept C126322002 @default.
• W2046236305 hasConcept C134018914 @default.
• W2046236305 hasConcept C185592680 @default.
• W2046236305 hasConcept C2777164284 @default.
• W2046236305 hasConcept C2777658017 @default.
• W2046236305 hasConcept C2778575703 @default.
• W2046236305 hasConcept C2778782382 @default.
• W2046236305 hasConcept C2779029589 @default.
• W2046236305 hasConcept C2779279165 @default.
• W2046236305 hasConcept C2780104272 @default.
• W2046236305 hasConcept C2988731192 @default.
• W2046236305 hasConcept C71315377 @default.
• W2046236305 hasConcept C71924100 @default.
• W2046236305 hasConcept C79191276 @default.
• W2046236305 hasConceptScore W2046236305C126322002 @default.
• W2046236305 hasConceptScore W2046236305C134018914 @default.
• W2046236305 hasConceptScore W2046236305C185592680 @default.
• W2046236305 hasConceptScore W2046236305C2777164284 @default.
• W2046236305 hasConceptScore W2046236305C2777658017 @default.
• W2046236305 hasConceptScore W2046236305C2778575703 @default.
• W2046236305 hasConceptScore W2046236305C2778782382 @default.
• W2046236305 hasConceptScore W2046236305C2779029589 @default.
• W2046236305 hasConceptScore W2046236305C2779279165 @default.
• W2046236305 hasConceptScore W2046236305C2780104272 @default.
• W2046236305 hasConceptScore W2046236305C2988731192 @default.
• W2046236305 hasConceptScore W2046236305C71315377 @default.
• W2046236305 hasConceptScore W2046236305C71924100 @default.
• W2046236305 hasConceptScore W2046236305C79191276 @default.
• W2046236305 hasLocation W20462363051 @default.
• W2046236305 hasLocation W20462363052 @default.
• W2046236305 hasOpenAccess W2046236305 @default.
• W2046236305 hasPrimaryLocation W20462363051 @default.
• W2046236305 hasRelatedWork W1968933575 @default.
• W2046236305 hasRelatedWork W1972504921 @default.
• W2046236305 hasRelatedWork W2024553435 @default.
• W2046236305 hasRelatedWork W2046236305 @default.
• W2046236305 hasRelatedWork W2062847990 @default.
• W2046236305 hasRelatedWork W2075442956 @default.

• next