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• W2046236557 startingPage "2628" @default.
• W2046236557 abstract "Synthesis of paclitaxel-penetratin (pAntp) constructs, in which the 2'- or 7-position of paclitaxel was used as the attachment site for linker connecting the drug and peptide moieties, is described. Paclitaxel-2'-pAntp[43-58]-NH(2)3b and paclitaxel-2'-pAntp[52-58]-NH(2)3c showed excellent antitumour activity against human lung and breast cancer cell lines. These conjugates were highly soluble and stable with a half-life of >8h under cell culture conditions. The drug-peptide conjugates may be therapeutically useful due to improved pharmaceutical properties." @default.
• W2046236557 created "2016-06-24" @default.
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• W2046236557 date "2006-05-01" @default.
• W2046236557 modified "2023-10-01" @default.
• W2046236557 title "Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin" @default.
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• W2046236557 doi "https://doi.org/10.1016/j.bmcl.2006.02.035" @default.
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