FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046238191> ?p ?o ?g. }

• W2046238191 endingPage "1034" @default.
• W2046238191 startingPage "1027" @default.
• W2046238191 abstract "The strength of the cytotoxic T lymphocyte (CTL) response is believed to influence the final outcome of hepatitis B virus (HBV) infection. Among the different CTL epitopes so far identified, the sequence 18-27 of the HBV nucleocapsid antigen is widely recognized by CTL of HLA-A2-positive patients with acute self-limited HBV infection, and represents the main component of a peptide-based therapeutic vaccine aimed at stimulating the antiviral CTL response in patients with chronic hepatitis B. In the present study, we further analyzed the features of this important HBV region by the following: 1) defining the contribution of individual residues of the epitope to the interaction with the T-cell receptor (TCR) and with the HLA-A0201 molecule; 2) assessing the antigenicity of this viral region in the context of the different HLA-A2 subtypes; and 3) testing whether this sequence can stimulate not only HLA-class I but also HLA class II restricted T-cell responses. A clear hierarchy was observed in the ability of individual residues to act as TCR or HLA binding sites. Furthermore, the sequence HBc18-27 was able to be recognized by specific CTL when presented in the context of different HLA-A2 subtypes. Finally, this HBV region was also found to stimulate HLA class II restricted T-cell responses. These data further increase the potential coverage and efficacy of therapeutic vaccines based on the HBc18-27 sequence." @default.
• W2046238191 created "2016-06-24" @default.
• W2046238191 creator A5005565231 @default.
• W2046238191 creator A5010966529 @default.
• W2046238191 creator A5031164159 @default.
• W2046238191 creator A5039286311 @default.
• W2046238191 creator A5041720192 @default.
• W2046238191 creator A5047066070 @default.
• W2046238191 creator A5055486206 @default.
• W2046238191 creator A5062001150 @default.
• W2046238191 creator A5070463166 @default.
• W2046238191 creator A5080620260 @default.
• W2046238191 date "1997-10-01" @default.
• W2046238191 modified "2023-09-23" @default.
• W2046238191 title "Molecular features of the hepatitis B virus nucleocapsid T-cell epitope 18-27: Interaction with HLA and T-cell receptor" @default.
• W2046238191 cites W1845254015 @default.
• W2046238191 cites W2022337477 @default.
• W2046238191 cites W2029836713 @default.
• W2046238191 cites W2035960239 @default.
• W2046238191 cites W2088165891 @default.
• W2046238191 cites W2175117246 @default.
• W2046238191 doi "https://doi.org/10.1002/hep.510260435" @default.
• W2046238191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9328331" @default.
• W2046238191 hasPublicationYear "1997" @default.
• W2046238191 type Work @default.
• W2046238191 sameAs 2046238191 @default.
• W2046238191 citedByCount "56" @default.
• W2046238191 countsByYear W20462381912012 @default.
• W2046238191 countsByYear W20462381912013 @default.
• W2046238191 countsByYear W20462381912014 @default.
• W2046238191 countsByYear W20462381912015 @default.
• W2046238191 countsByYear W20462381912018 @default.
• W2046238191 countsByYear W20462381912019 @default.
• W2046238191 countsByYear W20462381912020 @default.
• W2046238191 countsByYear W20462381912021 @default.
• W2046238191 countsByYear W20462381912022 @default.
• W2046238191 countsByYear W20462381912023 @default.
• W2046238191 crossrefType "journal-article" @default.
• W2046238191 hasAuthorship W2046238191A5005565231 @default.
• W2046238191 hasAuthorship W2046238191A5010966529 @default.
• W2046238191 hasAuthorship W2046238191A5031164159 @default.
• W2046238191 hasAuthorship W2046238191A5039286311 @default.
• W2046238191 hasAuthorship W2046238191A5041720192 @default.
• W2046238191 hasAuthorship W2046238191A5047066070 @default.
• W2046238191 hasAuthorship W2046238191A5055486206 @default.
• W2046238191 hasAuthorship W2046238191A5062001150 @default.
• W2046238191 hasAuthorship W2046238191A5070463166 @default.
• W2046238191 hasAuthorship W2046238191A5080620260 @default.
• W2046238191 hasBestOaLocation W20462381911 @default.
• W2046238191 hasConcept C147483822 @default.
• W2046238191 hasConcept C147969180 @default.
• W2046238191 hasConcept C151730666 @default.
• W2046238191 hasConcept C154317977 @default.
• W2046238191 hasConcept C159047783 @default.
• W2046238191 hasConcept C167672396 @default.
• W2046238191 hasConcept C188280979 @default.
• W2046238191 hasConcept C19317047 @default.
• W2046238191 hasConcept C195616568 @default.
• W2046238191 hasConcept C202751555 @default.
• W2046238191 hasConcept C203014093 @default.
• W2046238191 hasConcept C2522874641 @default.
• W2046238191 hasConcept C2776090121 @default.
• W2046238191 hasConcept C2779026604 @default.
• W2046238191 hasConcept C2779343474 @default.
• W2046238191 hasConcept C2780593183 @default.
• W2046238191 hasConcept C41007239 @default.
• W2046238191 hasConcept C54355233 @default.
• W2046238191 hasConcept C86803240 @default.
• W2046238191 hasConcept C8891405 @default.
• W2046238191 hasConceptScore W2046238191C147483822 @default.
• W2046238191 hasConceptScore W2046238191C147969180 @default.
• W2046238191 hasConceptScore W2046238191C151730666 @default.
• W2046238191 hasConceptScore W2046238191C154317977 @default.
• W2046238191 hasConceptScore W2046238191C159047783 @default.
• W2046238191 hasConceptScore W2046238191C167672396 @default.
• W2046238191 hasConceptScore W2046238191C188280979 @default.
• W2046238191 hasConceptScore W2046238191C19317047 @default.
• W2046238191 hasConceptScore W2046238191C195616568 @default.
• W2046238191 hasConceptScore W2046238191C202751555 @default.
• W2046238191 hasConceptScore W2046238191C203014093 @default.
• W2046238191 hasConceptScore W2046238191C2522874641 @default.
• W2046238191 hasConceptScore W2046238191C2776090121 @default.
• W2046238191 hasConceptScore W2046238191C2779026604 @default.
• W2046238191 hasConceptScore W2046238191C2779343474 @default.
• W2046238191 hasConceptScore W2046238191C2780593183 @default.
• W2046238191 hasConceptScore W2046238191C41007239 @default.
• W2046238191 hasConceptScore W2046238191C54355233 @default.
• W2046238191 hasConceptScore W2046238191C86803240 @default.
• W2046238191 hasConceptScore W2046238191C8891405 @default.
• W2046238191 hasIssue "4" @default.
• W2046238191 hasLocation W20462381911 @default.
• W2046238191 hasLocation W20462381912 @default.
• W2046238191 hasOpenAccess W2046238191 @default.
• W2046238191 hasPrimaryLocation W20462381911 @default.
• W2046238191 hasRelatedWork W2052483994 @default.
• W2046238191 hasRelatedWork W2053177727 @default.
• W2046238191 hasRelatedWork W2063316104 @default.
• W2046238191 hasRelatedWork W2063695575 @default.

• next