Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046239158> ?p ?o ?g. }
- W2046239158 endingPage "1204" @default.
- W2046239158 startingPage "1191" @default.
- W2046239158 abstract "Developing tissues require cells to undergo intricate processes to shift into appropriate niches. This requires a functional connection between adhesion-mediating events at the cell surface and a cytoskeletal reorganization to permit directed movement. A small number of proteins are proposed to link these processes. Here, we identify one candidate, Cindr, the sole Drosophila melanogaster member of the CD2AP/CIN85 family (this family has been previously implicated in a variety of processes). Using D. melanogaster retina, we demonstrate that Cindr links cell surface junctions (E-cadherin) and adhesion (Roughest) with multiple components of the actin cytoskeleton. Reducing cindr activity leads to defects in local cell movement and, consequently, tissue patterning and cell death. Cindr activity is required for normal localization of Drosophila E-cadherin and Roughest, and we show additional physical and functional links to multiple components of the actin cytoskeleton, including the actin-capping proteins capping protein alpha and capping protein beta. Together, these data demonstrate that Cindr is involved in dynamic cell rearrangement in an emerging epithelium." @default.
- W2046239158 created "2016-06-24" @default.
- W2046239158 creator A5018637906 @default.
- W2046239158 creator A5025899246 @default.
- W2046239158 creator A5071294259 @default.
- W2046239158 date "2008-03-24" @default.
- W2046239158 modified "2023-10-11" @default.
- W2046239158 title "The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning" @default.
- W2046239158 cites W1575542444 @default.
- W2046239158 cites W169724761 @default.
- W2046239158 cites W1964745905 @default.
- W2046239158 cites W1966275916 @default.
- W2046239158 cites W1967772460 @default.
- W2046239158 cites W1971686069 @default.
- W2046239158 cites W1983523339 @default.
- W2046239158 cites W1987202401 @default.
- W2046239158 cites W1989785405 @default.
- W2046239158 cites W1994331800 @default.
- W2046239158 cites W1998833659 @default.
- W2046239158 cites W2000186902 @default.
- W2046239158 cites W2001892266 @default.
- W2046239158 cites W2002769350 @default.
- W2046239158 cites W2005437897 @default.
- W2046239158 cites W2013082189 @default.
- W2046239158 cites W2014868351 @default.
- W2046239158 cites W2017302921 @default.
- W2046239158 cites W2019103273 @default.
- W2046239158 cites W2019286212 @default.
- W2046239158 cites W2026249219 @default.
- W2046239158 cites W2032534466 @default.
- W2046239158 cites W2036525096 @default.
- W2046239158 cites W2042608426 @default.
- W2046239158 cites W2046540619 @default.
- W2046239158 cites W2050251450 @default.
- W2046239158 cites W2052354634 @default.
- W2046239158 cites W2054749870 @default.
- W2046239158 cites W2070115275 @default.
- W2046239158 cites W2070191679 @default.
- W2046239158 cites W2082534341 @default.
- W2046239158 cites W2086030678 @default.
- W2046239158 cites W2088760718 @default.
- W2046239158 cites W2092561515 @default.
- W2046239158 cites W2096358172 @default.
- W2046239158 cites W2097709550 @default.
- W2046239158 cites W2105488539 @default.
- W2046239158 cites W2106613050 @default.
- W2046239158 cites W2110643873 @default.
- W2046239158 cites W2111372229 @default.
- W2046239158 cites W2115375361 @default.
- W2046239158 cites W2119693261 @default.
- W2046239158 cites W2121645313 @default.
- W2046239158 cites W2121647278 @default.
- W2046239158 cites W2123191693 @default.
- W2046239158 cites W2125087346 @default.
- W2046239158 cites W2125280399 @default.
- W2046239158 cites W2131819974 @default.
- W2046239158 cites W2139285785 @default.
- W2046239158 cites W2142988687 @default.
- W2046239158 cites W2144057920 @default.
- W2046239158 cites W2144444784 @default.
- W2046239158 cites W2147850775 @default.
- W2046239158 cites W2159935247 @default.
- W2046239158 cites W2165428261 @default.
- W2046239158 cites W2169754516 @default.
- W2046239158 cites W2170770662 @default.
- W2046239158 cites W4248277281 @default.
- W2046239158 doi "https://doi.org/10.1083/jcb.200706108" @default.
- W2046239158 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2290846" @default.
- W2046239158 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18362180" @default.
- W2046239158 hasPublicationYear "2008" @default.
- W2046239158 type Work @default.
- W2046239158 sameAs 2046239158 @default.
- W2046239158 citedByCount "60" @default.
- W2046239158 countsByYear W20462391582012 @default.
- W2046239158 countsByYear W20462391582013 @default.
- W2046239158 countsByYear W20462391582014 @default.
- W2046239158 countsByYear W20462391582015 @default.
- W2046239158 countsByYear W20462391582016 @default.
- W2046239158 countsByYear W20462391582017 @default.
- W2046239158 countsByYear W20462391582018 @default.
- W2046239158 countsByYear W20462391582019 @default.
- W2046239158 countsByYear W20462391582020 @default.
- W2046239158 countsByYear W20462391582021 @default.
- W2046239158 countsByYear W20462391582022 @default.
- W2046239158 countsByYear W20462391582023 @default.
- W2046239158 crossrefType "journal-article" @default.
- W2046239158 hasAuthorship W2046239158A5018637906 @default.
- W2046239158 hasAuthorship W2046239158A5025899246 @default.
- W2046239158 hasAuthorship W2046239158A5071294259 @default.
- W2046239158 hasBestOaLocation W20462391581 @default.
- W2046239158 hasConcept C104317684 @default.
- W2046239158 hasConcept C125705527 @default.
- W2046239158 hasConcept C142669718 @default.
- W2046239158 hasConcept C1491633281 @default.
- W2046239158 hasConcept C149402561 @default.
- W2046239158 hasConcept C2780104201 @default.
- W2046239158 hasConcept C2993400109 @default.
- W2046239158 hasConcept C54355233 @default.