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- W2046244014 abstract "Moxisylyte (or thymoxamine) is an α-adrenoceptor blocking agent used to reverse mydriasis. The drug molecule has an ester moiety which is vulnerable to acid and base catalyzed hydrolysis. Long-term storage of the drug at room temperature has not been possible because of this hydrolysis. An accelerated, stability-indicating assay was developed to study the hydrolysis and modify the formulation for room temperature storage (instead of refrigeration). Stability studies with pH variation and with β-cyclodextrins resulted in a formulation with dimethyl-β-cyclodextrin at pH 5.0. All other available β-cyclodextrins either accelerated the hydrolysis or had little effect." @default.
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- W2046244014 date "1993-10-01" @default.
- W2046244014 modified "2023-10-18" @default.
- W2046244014 title "Stabilization of aqueous thymoxamine using dimethyl-β-cyclodextrin" @default.
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- W2046244014 doi "https://doi.org/10.1016/0378-5173(93)90349-k" @default.
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