Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046244922> ?p ?o ?g. }
- W2046244922 endingPage "8913" @default.
- W2046244922 startingPage "8903" @default.
- W2046244922 abstract "Coordinated proteolysis of synaptic proteins is required for synaptic plasticity, but a mechanism for recruiting the ubiquitin-proteasome system (UPS) into dendritic spines is not known. NAC1 is a cocaine-regulated transcriptional protein that was found to complex with proteins in the UPS, including cullins and Mov34. NAC1 and the proteasome were cotranslocated from the nucleus into dendritic spines in cortical neurons in response to proteasome inhibition or disinhibiting synaptic activity with bicuculline. Bicuculline also produced a progressive accumulation of the proteasome and NAC1 in the postsynaptic density. Recruitment of the proteasome into dendrites and postsynaptic density by bicuculline was prevented in neurons from mice harboring an NAC1 gene deletion or in neurons transfected with mutated NAC1 lacking the proteasome binding domain. These experiments show that NAC1 modulates the translocation of the UPS from the nucleus into dendritic spines, thereby suggesting a potential missing link in the recruitment of necessary proteolysis machinery for synaptic remodeling." @default.
- W2046244922 created "2016-06-24" @default.
- W2046244922 creator A5001809533 @default.
- W2046244922 creator A5008544667 @default.
- W2046244922 creator A5008892103 @default.
- W2046244922 creator A5010929684 @default.
- W2046244922 creator A5018511567 @default.
- W2046244922 creator A5022907334 @default.
- W2046244922 creator A5027562840 @default.
- W2046244922 creator A5052217592 @default.
- W2046244922 creator A5059610777 @default.
- W2046244922 creator A5078035590 @default.
- W2046244922 date "2007-08-15" @default.
- W2046244922 modified "2023-09-23" @default.
- W2046244922 title "NAC1 Regulates the Recruitment of the Proteasome Complex into Dendritic Spines" @default.
- W2046244922 cites W1487695731 @default.
- W2046244922 cites W1551589974 @default.
- W2046244922 cites W1598659526 @default.
- W2046244922 cites W1608902359 @default.
- W2046244922 cites W1632423539 @default.
- W2046244922 cites W1644096094 @default.
- W2046244922 cites W1964605487 @default.
- W2046244922 cites W1966670273 @default.
- W2046244922 cites W1967292256 @default.
- W2046244922 cites W1967950532 @default.
- W2046244922 cites W1968883861 @default.
- W2046244922 cites W1977077283 @default.
- W2046244922 cites W1980574091 @default.
- W2046244922 cites W1984732337 @default.
- W2046244922 cites W1994743127 @default.
- W2046244922 cites W1998033984 @default.
- W2046244922 cites W2000874341 @default.
- W2046244922 cites W2015504794 @default.
- W2046244922 cites W2017100487 @default.
- W2046244922 cites W2017277436 @default.
- W2046244922 cites W2021782736 @default.
- W2046244922 cites W2027923741 @default.
- W2046244922 cites W2029333902 @default.
- W2046244922 cites W2036040051 @default.
- W2046244922 cites W2037836204 @default.
- W2046244922 cites W2037873496 @default.
- W2046244922 cites W2038719756 @default.
- W2046244922 cites W2043006474 @default.
- W2046244922 cites W2047946233 @default.
- W2046244922 cites W2050658556 @default.
- W2046244922 cites W2054508664 @default.
- W2046244922 cites W2059515537 @default.
- W2046244922 cites W2060347762 @default.
- W2046244922 cites W2062588464 @default.
- W2046244922 cites W2063523634 @default.
- W2046244922 cites W2084144301 @default.
- W2046244922 cites W2085844654 @default.
- W2046244922 cites W2088504425 @default.
- W2046244922 cites W2106372172 @default.
- W2046244922 cites W2119271253 @default.
- W2046244922 cites W2132728901 @default.
- W2046244922 cites W2147359625 @default.
- W2046244922 cites W2147368157 @default.
- W2046244922 cites W2150123812 @default.
- W2046244922 cites W2151538478 @default.
- W2046244922 cites W2157301095 @default.
- W2046244922 cites W2162971521 @default.
- W2046244922 cites W2168713325 @default.
- W2046244922 cites W2180590412 @default.
- W2046244922 cites W2356498392 @default.
- W2046244922 cites W2396010915 @default.
- W2046244922 cites W4253384254 @default.
- W2046244922 doi "https://doi.org/10.1523/jneurosci.1571-07.2007" @default.
- W2046244922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6672176" @default.
- W2046244922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17699672" @default.
- W2046244922 hasPublicationYear "2007" @default.
- W2046244922 type Work @default.
- W2046244922 sameAs 2046244922 @default.
- W2046244922 citedByCount "51" @default.
- W2046244922 countsByYear W20462449222012 @default.
- W2046244922 countsByYear W20462449222013 @default.
- W2046244922 countsByYear W20462449222014 @default.
- W2046244922 countsByYear W20462449222015 @default.
- W2046244922 countsByYear W20462449222016 @default.
- W2046244922 countsByYear W20462449222017 @default.
- W2046244922 countsByYear W20462449222019 @default.
- W2046244922 countsByYear W20462449222021 @default.
- W2046244922 countsByYear W20462449222022 @default.
- W2046244922 countsByYear W20462449222023 @default.
- W2046244922 crossrefType "journal-article" @default.
- W2046244922 hasAuthorship W2046244922A5001809533 @default.
- W2046244922 hasAuthorship W2046244922A5008544667 @default.
- W2046244922 hasAuthorship W2046244922A5008892103 @default.
- W2046244922 hasAuthorship W2046244922A5010929684 @default.
- W2046244922 hasAuthorship W2046244922A5018511567 @default.
- W2046244922 hasAuthorship W2046244922A5022907334 @default.
- W2046244922 hasAuthorship W2046244922A5027562840 @default.
- W2046244922 hasAuthorship W2046244922A5052217592 @default.
- W2046244922 hasAuthorship W2046244922A5059610777 @default.
- W2046244922 hasAuthorship W2046244922A5078035590 @default.
- W2046244922 hasBestOaLocation W20462449221 @default.
- W2046244922 hasConcept C148762608 @default.
- W2046244922 hasConcept C168258287 @default.