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- W2046245541 abstract "To evaluate the correlation between antinucleosome antibodies and disease activity in patients with systemic lupus erythematosus (SLE).We evaluated antinucleosome antibodies (by ELISA) in 48 SLE patients. They were divided in 2 groups: positive (Group A, nr = 18) and negative (Group B, nr=30). The groups were evaluated for antinucleosome antibodies and for clinical, humoral parameters (hemoglobin, blood cell count, urinanalysis, ESR, ANA, anti-dsDNA, anticardiolipin antibodies, LAC), and ECLAM.C3,C4, and hemoglobin were lower in Group A than (vs) group B (C3: 0.61 +/- 0.16 g/L vs 0.88 +/- 0.08 g/L, p < 0.001; C4: 0.086 +/- 0.03 g/L vs 0.18 +/- 0.07 g/L, p < 0.05; hemoglobin: 8.7 +/- 5.8 g/dL vs 12.7 +/- 1.44 g/dL; p < 0.02). ECLAM was higher in group A 7.56 +/- 2.19 vs group B 4.67 +/- 1.35 (p < 0.001). Urinary sediment was more altered in group A (88.8%) vs group B (33.3%; p < 0.001).We found a correlation between antinucleosome antibodies and SLE disease activity as expressed by the higher ECLAM score in group A." @default.
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- W2046245541 date "2003-01-01" @default.
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- W2046245541 title "Disease activity and antinucleosome antibodies in systemic lupus erythematosus" @default.
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- W2046245541 doi "https://doi.org/10.1080/03009740310000391" @default.
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