Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046249849> ?p ?o ?g. }
- W2046249849 endingPage "9934" @default.
- W2046249849 startingPage "9934" @default.
- W2046249849 abstract "Graphene oxide (GO) has been extensively studied for potential biomedical applications. Meanwhile, potential GO toxicity arises in both biomedical applications and non-biomedical products where environmental exposures may occur. In the present study, we examined the potential adverse effects of GO and the underlying mechanism using nematode Caenorhabditis elegans as the assay system. We compared the in vivo effects of GO between acute exposure and prolonged exposure, and found that prolonged exposure to 0.5–100 mg L−1 of GO caused damage on functions of both primary (intestine) and secondary (neuron and reproductive organ) targeted organs. In the intestine, ROS production was significantly correlated with the formation of adverse effects on functions of both primary and secondary targeted organs. GO could be translocated into intestinal cells with loss of microvilli, and distributed to be adjacent to or surrounding mitochondria. Prolonged exposure to GO resulted in a hyper-permeable state of the intestinal barrier, an increase in mean defecation cycle length, and alteration of genes required for intestinal development and defecation behavior. Thus, our data suggest that prolonged exposure to GO may cause potential risk to environmental organisms after release into the environment. GO toxicity may be due to the combinational effects of oxidative stress in the intestinal barrier, enhanced permeability of the biological barrier, and suppressed defecation behavior in C. elegans." @default.
- W2046249849 created "2016-06-24" @default.
- W2046249849 creator A5001797690 @default.
- W2046249849 creator A5009081304 @default.
- W2046249849 creator A5025286626 @default.
- W2046249849 creator A5025751238 @default.
- W2046249849 creator A5043286887 @default.
- W2046249849 creator A5076575975 @default.
- W2046249849 date "2013-01-01" @default.
- W2046249849 modified "2023-10-16" @default.
- W2046249849 title "Contributions of altered permeability of intestinal barrier and defecation behavior to toxicity formation from graphene oxide in nematode Caenorhabditis elegans" @default.
- W2046249849 cites W1504117188 @default.
- W2046249849 cites W1944127002 @default.
- W2046249849 cites W1965757104 @default.
- W2046249849 cites W1969806459 @default.
- W2046249849 cites W1973973036 @default.
- W2046249849 cites W1976787731 @default.
- W2046249849 cites W1980419364 @default.
- W2046249849 cites W1985062429 @default.
- W2046249849 cites W1985737642 @default.
- W2046249849 cites W1985847194 @default.
- W2046249849 cites W1989322161 @default.
- W2046249849 cites W1992670984 @default.
- W2046249849 cites W1992836764 @default.
- W2046249849 cites W1997172038 @default.
- W2046249849 cites W1997990070 @default.
- W2046249849 cites W1998623254 @default.
- W2046249849 cites W1999378798 @default.
- W2046249849 cites W2006983532 @default.
- W2046249849 cites W2009789613 @default.
- W2046249849 cites W2012588499 @default.
- W2046249849 cites W2013328140 @default.
- W2046249849 cites W2017581710 @default.
- W2046249849 cites W2022394525 @default.
- W2046249849 cites W2023590633 @default.
- W2046249849 cites W2026533340 @default.
- W2046249849 cites W2027157078 @default.
- W2046249849 cites W2030677057 @default.
- W2046249849 cites W2031842813 @default.
- W2046249849 cites W2033050279 @default.
- W2046249849 cites W2037360063 @default.
- W2046249849 cites W2042466918 @default.
- W2046249849 cites W2046351755 @default.
- W2046249849 cites W2053079503 @default.
- W2046249849 cites W2054898480 @default.
- W2046249849 cites W2058805981 @default.
- W2046249849 cites W2060828364 @default.
- W2046249849 cites W2061817247 @default.
- W2046249849 cites W2065672831 @default.
- W2046249849 cites W2066549755 @default.
- W2046249849 cites W2068025923 @default.
- W2046249849 cites W2069501305 @default.
- W2046249849 cites W2073454755 @default.
- W2046249849 cites W2075771130 @default.
- W2046249849 cites W2078792724 @default.
- W2046249849 cites W2078933633 @default.
- W2046249849 cites W2080321548 @default.
- W2046249849 cites W2081705834 @default.
- W2046249849 cites W2084163815 @default.
- W2046249849 cites W2084187185 @default.
- W2046249849 cites W2084304480 @default.
- W2046249849 cites W2085961531 @default.
- W2046249849 cites W2086627614 @default.
- W2046249849 cites W2088693256 @default.
- W2046249849 cites W2092392725 @default.
- W2046249849 cites W2093198338 @default.
- W2046249849 cites W2093384479 @default.
- W2046249849 cites W2098505308 @default.
- W2046249849 cites W2102067807 @default.
- W2046249849 cites W2111845774 @default.
- W2046249849 cites W2117326659 @default.
- W2046249849 cites W2127574238 @default.
- W2046249849 cites W2132556925 @default.
- W2046249849 cites W2139208773 @default.
- W2046249849 cites W2148259790 @default.
- W2046249849 cites W2148427274 @default.
- W2046249849 cites W2148465347 @default.
- W2046249849 cites W2152311269 @default.
- W2046249849 cites W2154738003 @default.
- W2046249849 cites W2325811345 @default.
- W2046249849 cites W2355982675 @default.
- W2046249849 cites W4233194460 @default.
- W2046249849 cites W4243271251 @default.
- W2046249849 cites W4664523 @default.
- W2046249849 doi "https://doi.org/10.1039/c3nr02084c" @default.
- W2046249849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23986404" @default.
- W2046249849 hasPublicationYear "2013" @default.
- W2046249849 type Work @default.
- W2046249849 sameAs 2046249849 @default.
- W2046249849 citedByCount "161" @default.
- W2046249849 countsByYear W20462498492014 @default.
- W2046249849 countsByYear W20462498492015 @default.
- W2046249849 countsByYear W20462498492016 @default.
- W2046249849 countsByYear W20462498492017 @default.
- W2046249849 countsByYear W20462498492018 @default.
- W2046249849 countsByYear W20462498492019 @default.
- W2046249849 countsByYear W20462498492020 @default.
- W2046249849 countsByYear W20462498492021 @default.