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- W2046255503 endingPage "53" @default.
- W2046255503 startingPage "43" @default.
- W2046255503 abstract "Neonatal brain injury is an important cause of death and neurodevelopmental delay. Multiple pathways of oxidant stress, inflammation, and excitotoxicity lead to both early and late phases of cell damage and death. Therapies targeting these different pathways have shown potential in protecting the brain from ongoing injury. More recent therapies, such as growth factors, have demonstrated an ability to increase cell proliferation and repair over longer periods of time. Even though hypothermia, which decreases cerebral metabolism and possibly affects other mechanisms, may show some benefit in particular cases, no widely effective therapeutic interventions for human neonates exist. In this review, we summarize recent findings in neuroprotection and neurogenesis for the immature brain, including combination therapy to optimize repair." @default.
- W2046255503 created "2016-06-24" @default.
- W2046255503 creator A5003672781 @default.
- W2046255503 creator A5034975985 @default.
- W2046255503 date "2008-10-01" @default.
- W2046255503 modified "2023-10-16" @default.
- W2046255503 title "Therapeutics for neonatal brain injury" @default.
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