FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046263195> ?p ?o ?g. }

• W2046263195 endingPage "96" @default.
• W2046263195 startingPage "83" @default.
• W2046263195 abstract "A principle objective in chemotherapy is the development of modalities capable of selectively destroying malignant cells while sparing normal tissues. One new approach to selective photochemotherapy, antibody-targeted photolysis (ATPL) uses photosensitizers (PS) coupled to monoclonal antibodies (MAbs) which bind to cell surface antigens on malignant cells. Selective destruction of human T leukemia cells (HBP-ALL) was accomplished by coupling the efficient PS chlorin e(6) to an anti-T cell MAb using dextran carriers. Conjugates with chlorin: MAb ratios of 30:1 retained > 85% MA b binding activity, and had a quantum yield for singlet oxygen production of 0.7 +/- 0.1, the same as that of free chlorin e(6). Cell killing was dependent on the doses of both MAb-PS and 630-670 nm light and occurred only in target cell populations which bound the MAb. On the order of 10(10) singlet oxygen molecules were necessary to kill a cell. A second approach to specific photochemotherapy, selective carcinoma cell photolysis (SCCP), relies on preferential accumulation of certain cationic PS by carcinoma cell mitochondria. We have evaluated several classes of cationic dyes, and in the case of N,N'-bis-(2-ethyl-1,3-dioxolane)-kryptocyanine (EDKC) and some of its analogs, have demonstrated highly selective killing of human squamous cell, bladder and colon carcinoma cells in vitro. In isolated mitochondria, EDKC uptake and fluorescence depended on membrane potential, and the dye specifically photosensitized damage to Complex I in the electron transport chain. N,N'-bis-(2-ethyl-1,3-dioxolane)-kryptocyanine and some of its analogs accumulated within subcutaneous xenografts of human tumors in nude mice with tumor:skin ratios > 8. Photoirradiation caused significant inhibition of tumor growth, without cutaneous phototoxicity." @default.
• W2046263195 created "2016-06-24" @default.
• W2046263195 creator A5020879035 @default.
• W2046263195 creator A5037227973 @default.
• W2046263195 creator A5038970476 @default.
• W2046263195 creator A5055658784 @default.
• W2046263195 creator A5062127809 @default.
• W2046263195 creator A5068177167 @default.
• W2046263195 creator A5069143717 @default.
• W2046263195 creator A5083965996 @default.
• W2046263195 date "1987-07-01" @default.
• W2046263195 modified "2023-10-10" @default.
• W2046263195 title "STRATEGIES FOR SELECTIVE CANCER PHOTOCHEMOTHERAPY: ANTIBODY-TARGETED and SELECTIVE CARCINOMA CELL PHOTOLYSIS" @default.
• W2046263195 cites W1495376651 @default.
• W2046263195 cites W1533725999 @default.
• W2046263195 cites W1603443874 @default.
• W2046263195 cites W169027326 @default.
• W2046263195 cites W1775749144 @default.
• W2046263195 cites W1975812534 @default.
• W2046263195 cites W1983664030 @default.
• W2046263195 cites W1995935632 @default.
• W2046263195 cites W2005407680 @default.
• W2046263195 cites W2018460248 @default.
• W2046263195 cites W2019606258 @default.
• W2046263195 cites W2025231227 @default.
• W2046263195 cites W2026278025 @default.
• W2046263195 cites W2029754737 @default.
• W2046263195 cites W2030358987 @default.
• W2046263195 cites W2033256212 @default.
• W2046263195 cites W2042301343 @default.
• W2046263195 cites W2043133764 @default.
• W2046263195 cites W2043633201 @default.
• W2046263195 cites W2045934824 @default.
• W2046263195 cites W2046030853 @default.
• W2046263195 cites W2048018154 @default.
• W2046263195 cites W2049857745 @default.
• W2046263195 cites W2067957471 @default.
• W2046263195 cites W2074968973 @default.
• W2046263195 cites W2075288046 @default.
• W2046263195 cites W2084814947 @default.
• W2046263195 cites W2086306477 @default.
• W2046263195 cites W2091937732 @default.
• W2046263195 cites W2127463260 @default.
• W2046263195 cites W2160029055 @default.
• W2046263195 cites W21868425 @default.
• W2046263195 cites W2314782572 @default.
• W2046263195 cites W2428438200 @default.
• W2046263195 cites W365687254 @default.
• W2046263195 cites W4235595124 @default.
• W2046263195 doi "https://doi.org/10.1111/j.1751-1097.1987.tb04740.x" @default.
• W2046263195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3615636" @default.
• W2046263195 hasPublicationYear "1987" @default.
• W2046263195 type Work @default.
• W2046263195 sameAs 2046263195 @default.
• W2046263195 citedByCount "80" @default.
• W2046263195 countsByYear W20462631952014 @default.
• W2046263195 countsByYear W20462631952015 @default.
• W2046263195 countsByYear W20462631952016 @default.
• W2046263195 countsByYear W20462631952018 @default.
• W2046263195 countsByYear W20462631952020 @default.
• W2046263195 countsByYear W20462631952021 @default.
• W2046263195 crossrefType "journal-article" @default.
• W2046263195 hasAuthorship W2046263195A5020879035 @default.
• W2046263195 hasAuthorship W2046263195A5037227973 @default.
• W2046263195 hasAuthorship W2046263195A5038970476 @default.
• W2046263195 hasAuthorship W2046263195A5055658784 @default.
• W2046263195 hasAuthorship W2046263195A5062127809 @default.
• W2046263195 hasAuthorship W2046263195A5068177167 @default.
• W2046263195 hasAuthorship W2046263195A5069143717 @default.
• W2046263195 hasAuthorship W2046263195A5083965996 @default.
• W2046263195 hasConcept C121608353 @default.
• W2046263195 hasConcept C12554922 @default.
• W2046263195 hasConcept C1491633281 @default.
• W2046263195 hasConcept C159654299 @default.
• W2046263195 hasConcept C178790620 @default.
• W2046263195 hasConcept C185592680 @default.
• W2046263195 hasConcept C203014093 @default.
• W2046263195 hasConcept C2777516457 @default.
• W2046263195 hasConcept C2781323092 @default.
• W2046263195 hasConcept C502942594 @default.
• W2046263195 hasConcept C540031477 @default.
• W2046263195 hasConcept C542903549 @default.
• W2046263195 hasConcept C54355233 @default.
• W2046263195 hasConcept C55493867 @default.
• W2046263195 hasConcept C81885089 @default.
• W2046263195 hasConcept C86803240 @default.
• W2046263195 hasConcept C96232424 @default.
• W2046263195 hasConceptScore W2046263195C121608353 @default.
• W2046263195 hasConceptScore W2046263195C12554922 @default.
• W2046263195 hasConceptScore W2046263195C1491633281 @default.
• W2046263195 hasConceptScore W2046263195C159654299 @default.
• W2046263195 hasConceptScore W2046263195C178790620 @default.
• W2046263195 hasConceptScore W2046263195C185592680 @default.
• W2046263195 hasConceptScore W2046263195C203014093 @default.
• W2046263195 hasConceptScore W2046263195C2777516457 @default.
• W2046263195 hasConceptScore W2046263195C2781323092 @default.
• W2046263195 hasConceptScore W2046263195C502942594 @default.
• W2046263195 hasConceptScore W2046263195C540031477 @default.

• next