Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046266521> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2046266521 endingPage "321" @default.
- W2046266521 startingPage "315" @default.
- W2046266521 abstract "ABSTRACT: Peptides representing sequences of the beta subunit of HCG (Cys-(Pro)6-111–145 and 109–145) were coupled to tetanus toxoid (TT) and the resultant conjugates used to test the ability of eight experimental adjuvants and six different vehicles for enhancing antibody responses to the peptides in inbred strains of mice (C3H/He, C57BL/6, DBA/1, and SJL) and outbred rabbits. Antibody levels reactive to both 125I-peptides and 125I-HCG were used as criteria of efficacy of these adjuvants and vehicles. In most experiments, groups of animals were immunized with conjugates in complete Freund's adjuvant (CFA) for comparison. Two hydrophilic adjuvants-NAc-nor-Mur-L.ala-D.isoGln, CGP 11,637 and NGlycol-nor-Mur-L.α-abu-D.isoGln, DT-1-were consistently the most effective in stimulating antibody production to both peptides and HCG. An emulsion containing squalene-water stabilized with arlacel A proved to be superior to other vehicles tested for administering conjugates and adjuvants to animals. Antibody levels produced by animals with different genetic backgrounds were shown to be polymorphic with respect to experimental adjuvants, but responses among groups using the same adjuvant and different vehicles were more consistent. Data were obtained suggesting that the coupling of a peptide antigen and a peptide adjuvant to the same carrier holds promise as a model for vaccine development." @default.
- W2046266521 created "2016-06-24" @default.
- W2046266521 creator A5044374235 @default.
- W2046266521 creator A5047185456 @default.
- W2046266521 creator A5072480228 @default.
- W2046266521 creator A5088532001 @default.
- W2046266521 creator A5090843532 @default.
- W2046266521 date "1981-12-01" @default.
- W2046266521 modified "2023-10-18" @default.
- W2046266521 title "Preparation and Formulation of a Human Chorionic Gonadotropin Antifertility Vaccine: Selection of Adjuvant and Vehicle*" @default.
- W2046266521 cites W2029803792 @default.
- W2046266521 cites W2046266521 @default.
- W2046266521 cites W2057297514 @default.
- W2046266521 cites W2408835434 @default.
- W2046266521 doi "https://doi.org/10.1111/j.1600-0897.1981.tb00064.x" @default.
- W2046266521 hasPublicationYear "1981" @default.
- W2046266521 type Work @default.
- W2046266521 sameAs 2046266521 @default.
- W2046266521 citedByCount "50" @default.
- W2046266521 countsByYear W20462665212013 @default.
- W2046266521 countsByYear W20462665212015 @default.
- W2046266521 crossrefType "journal-article" @default.
- W2046266521 hasAuthorship W2046266521A5044374235 @default.
- W2046266521 hasAuthorship W2046266521A5047185456 @default.
- W2046266521 hasAuthorship W2046266521A5072480228 @default.
- W2046266521 hasAuthorship W2046266521A5088532001 @default.
- W2046266521 hasAuthorship W2046266521A5090843532 @default.
- W2046266521 hasConcept C147483822 @default.
- W2046266521 hasConcept C159654299 @default.
- W2046266521 hasConcept C185592680 @default.
- W2046266521 hasConcept C203014093 @default.
- W2046266521 hasConcept C2775948956 @default.
- W2046266521 hasConcept C2777351567 @default.
- W2046266521 hasConcept C2777863537 @default.
- W2046266521 hasConcept C2779281246 @default.
- W2046266521 hasConcept C2779351315 @default.
- W2046266521 hasConcept C2780801004 @default.
- W2046266521 hasConcept C55493867 @default.
- W2046266521 hasConcept C71315377 @default.
- W2046266521 hasConcept C86803240 @default.
- W2046266521 hasConceptScore W2046266521C147483822 @default.
- W2046266521 hasConceptScore W2046266521C159654299 @default.
- W2046266521 hasConceptScore W2046266521C185592680 @default.
- W2046266521 hasConceptScore W2046266521C203014093 @default.
- W2046266521 hasConceptScore W2046266521C2775948956 @default.
- W2046266521 hasConceptScore W2046266521C2777351567 @default.
- W2046266521 hasConceptScore W2046266521C2777863537 @default.
- W2046266521 hasConceptScore W2046266521C2779281246 @default.
- W2046266521 hasConceptScore W2046266521C2779351315 @default.
- W2046266521 hasConceptScore W2046266521C2780801004 @default.
- W2046266521 hasConceptScore W2046266521C55493867 @default.
- W2046266521 hasConceptScore W2046266521C71315377 @default.
- W2046266521 hasConceptScore W2046266521C86803240 @default.
- W2046266521 hasIssue "6" @default.
- W2046266521 hasLocation W20462665211 @default.
- W2046266521 hasOpenAccess W2046266521 @default.
- W2046266521 hasPrimaryLocation W20462665211 @default.
- W2046266521 hasRelatedWork W1956338949 @default.
- W2046266521 hasRelatedWork W1957454201 @default.
- W2046266521 hasRelatedWork W2011008268 @default.
- W2046266521 hasRelatedWork W2053690527 @default.
- W2046266521 hasRelatedWork W2059661498 @default.
- W2046266521 hasRelatedWork W2089340769 @default.
- W2046266521 hasRelatedWork W2114961589 @default.
- W2046266521 hasRelatedWork W2894566990 @default.
- W2046266521 hasRelatedWork W4308308854 @default.
- W2046266521 hasRelatedWork W4313382156 @default.
- W2046266521 hasVolume "1" @default.
- W2046266521 isParatext "false" @default.
- W2046266521 isRetracted "false" @default.
- W2046266521 magId "2046266521" @default.
- W2046266521 workType "article" @default.