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• W2046268535 abstract "In altricial rodents, maternal influences entrain the developing circadian system in the perinatal period before the capacity to respond directly to photic cues develops. The aim of these studies was to investigate the potential role of dopamine in this process in the Siberian hamster. An initial study investigated the ontogeny of retinal innervation of the suprachiasmatic nuclei (SCN) by using cholera toxin B subunit as a tracer. This revealed that retinal fibres first innervate the SCN on postnatal day 3 (PD3), and ingrowth of fibres is extensive by PD6. In situ hybridisation studies revealed the presence of D1-dopamine receptor (D1-R) mRNA in the SCN on PD2, and levels of expression were similar in PD6 pups and adult hamsters. Immunocytochemical staining for tyrosine hydroxylase revealed abundant catecholaminergic fibres within the ventromedial zone of the SCN from the day of birth through PD20; however, in contrast, few fibres were present in adult SCN. Dopamine-β-hydroxylase-immunoreactive fibres were absent from the neonatal and adult SCN, suggesting that the fibres in the SCN are dopaminergic. The function of this dopaminergic system was investigated by determining the effects of D1-R agonists on the expression of the immediate-early gene c-fos in the SCN. This was assessed in pups ages PD1– PD5 by in situ hybridisation and immunocytochemical localisation of its protein product. No induction was seen in the SCN, in marked contrast to studies in the developing rat. A final series of studies investigated dopaminergic function by determining whether a D1-agonist could induce phosphorylation of Ca2+/cyclic AMP response element-binding protein (CREB) on Ser133. Hypothalamic slices containing SCN taken from PD1 and PD2 hamsters were treated with D1-R agonists, and levels of phosphorylated CREB were assayed by Western blots. Phosphorylation of CREB was stimulated by D1-R agonists in both Syrian and Siberian hamster hypothalamus, but the response was far greater in Syrian hamster tissue (+138% ± 28%) than in Siberian hamster tissue (+43% ± 11%). Although the anatomical studies demonstrate the existence of a dopaminergic system in the SCN of the early postnatal Siberian hamster, the unresponsiveness of c-fos expression and the relative lack of phosphorylation of CREB after D1-R activation suggests a diminished role for dopamine in the regulation of circadian events during the postnatal period in this species. J. Comp. Neurol. 408:73–96, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2046268535 created "2016-06-24" @default.
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• W2046268535 date "1999-05-24" @default.
• W2046268535 modified "2023-10-14" @default.
• W2046268535 title "Anatomical and functional characterisation of a dopaminergic system in the suprachiasmatic nucleus of the neonatal siberian hamster" @default.
• W2046268535 cites W1523073977 @default.
• W2046268535 cites W1583476908 @default.
• W2046268535 cites W1585713057 @default.
• W2046268535 cites W1625578528 @default.
• W2046268535 cites W1964108939 @default.
• W2046268535 cites W1968602579 @default.
• W2046268535 cites W1971598129 @default.
• W2046268535 cites W1978224056 @default.
• W2046268535 cites W1980363518 @default.
• W2046268535 cites W1980740786 @default.
• W2046268535 cites W1981626589 @default.
• W2046268535 cites W1984383528 @default.
• W2046268535 cites W1985474802 @default.
• W2046268535 cites W1986153364 @default.
• W2046268535 cites W1988482327 @default.
• W2046268535 cites W1989336944 @default.
• W2046268535 cites W1994705298 @default.
• W2046268535 cites W1995494474 @default.
• W2046268535 cites W1996475362 @default.
• W2046268535 cites W1997420133 @default.
• W2046268535 cites W1998448534 @default.
• W2046268535 cites W2002988343 @default.
• W2046268535 cites W2003150621 @default.
• W2046268535 cites W2004094484 @default.
• W2046268535 cites W2004323757 @default.
• W2046268535 cites W2004963533 @default.
• W2046268535 cites W2008043162 @default.
• W2046268535 cites W2012392333 @default.
• W2046268535 cites W2015402598 @default.
• W2046268535 cites W2016567166 @default.
• W2046268535 cites W2016720840 @default.
• W2046268535 cites W2018251374 @default.
• W2046268535 cites W2022123095 @default.
• W2046268535 cites W2024450505 @default.
• W2046268535 cites W2034248013 @default.
• W2046268535 cites W2037870935 @default.
• W2046268535 cites W2039724227 @default.
• W2046268535 cites W2040699715 @default.
• W2046268535 cites W2040777203 @default.
• W2046268535 cites W2042001904 @default.
• W2046268535 cites W2043417320 @default.
• W2046268535 cites W2045073877 @default.
• W2046268535 cites W2049273715 @default.
• W2046268535 cites W2049362518 @default.
• W2046268535 cites W2051577534 @default.
• W2046268535 cites W2051854344 @default.
• W2046268535 cites W2054990893 @default.
• W2046268535 cites W2055043387 @default.
• W2046268535 cites W2056741047 @default.
• W2046268535 cites W2058626517 @default.
• W2046268535 cites W2058636883 @default.
• W2046268535 cites W2058703825 @default.
• W2046268535 cites W2061311147 @default.
• W2046268535 cites W2071997711 @default.
• W2046268535 cites W2072061221 @default.
• W2046268535 cites W2077108130 @default.
• W2046268535 cites W2079265354 @default.
• W2046268535 cites W2080521355 @default.
• W2046268535 cites W2081917000 @default.
• W2046268535 cites W2082188651 @default.
• W2046268535 cites W2083855242 @default.
• W2046268535 cites W2084530213 @default.
• W2046268535 cites W2086392770 @default.
• W2046268535 cites W2086887849 @default.
• W2046268535 cites W2093710529 @default.
• W2046268535 cites W2095275140 @default.
• W2046268535 cites W2115736681 @default.
• W2046268535 cites W2118182233 @default.
• W2046268535 cites W2130807836 @default.
• W2046268535 cites W2143802707 @default.
• W2046268535 cites W2157311085 @default.
• W2046268535 cites W2159905857 @default.
• W2046268535 cites W2167345246 @default.
• W2046268535 doi "https://doi.org/10.1002/(sici)1096-9861(19990524)408:1<73::aid-cne6>3.0.co;2-5" @default.
• W2046268535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10331581" @default.
• W2046268535 hasPublicationYear "1999" @default.
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