FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046276677> ?p ?o ?g. }

• W2046276677 abstract "The human Islet Amyloid Polypeptide (hIAPP) is the major constituent of amyloid deposits in pancreatic islets of type-II diabetes. IAPP is secreted together with insulin from the acidic secretory granules at a low pH of approximately 5.5 to the extracellular environment at a neutral pH. The increased accumulation of extracellular hIAPP in diabetes indicates that changes in pH may promote amyloid formation. To gain insights and underlying mechanisms of the pH effect on hIAPP fibrillogenesis, all-atom molecular dynamics simulations in explicit solvent model were performed to study the structural properties of five hIAPP protofibrillar oligomers, under acidic and neutral pH, respectively. In consistent with experimental findings, simulation results show that acidic pH is not conducive to the structural stability of these oligomers. This provides a direct evidence for a recent experiment [L. Khemtemourian, E. Domenech, J. P. F. Doux, M. C. Koorengevel, and J. A. Killian, J. Am. Chem. Soc. 133, 15598 (2011)]10.1021/ja205007j, which suggests that acidic pH inhibits the fibril formation of hIAPP. In addition, a complementary coarse-grained simulation shows the repulsive electrostatic interactions among charged His18 residues slow down the dimerization process of hIAPP by twofold. Besides, our all-atom simulations reveal acidic pH mainly affects the local structure around residue His18 by destroying the surrounding hydrogen-bonding network, due to the repulsive interactions between protonated interchain His18 residues at acidic pH. It is also disclosed that the local interactions nearby His18 operating between adjacent β-strands trigger the structural transition, which gives hints to the experimental findings that the rate of hIAPP fibril formation and the morphologies of the fibrillar structures are strongly pH-dependent." @default.
• W2046276677 created "2016-06-24" @default.
• W2046276677 creator A5045389074 @default.
• W2046276677 creator A5064842058 @default.
• W2046276677 creator A5066791109 @default.
• W2046276677 creator A5071286986 @default.
• W2046276677 date "2013-08-01" @default.
• W2046276677 modified "2023-09-30" @default.
• W2046276677 title "Acidic pH retards the fibrillization of human islet amyloid polypeptide due to electrostatic repulsion of histidines" @default.
• W2046276677 cites W1552415503 @default.
• W2046276677 cites W1831484924 @default.
• W2046276677 cites W1936543486 @default.
• W2046276677 cites W1964172387 @default.
• W2046276677 cites W1964727310 @default.
• W2046276677 cites W1965649701 @default.
• W2046276677 cites W1967239474 @default.
• W2046276677 cites W1970166721 @default.
• W2046276677 cites W1971801685 @default.
• W2046276677 cites W1976851725 @default.
• W2046276677 cites W1981021420 @default.
• W2046276677 cites W1984964811 @default.
• W2046276677 cites W1985263866 @default.
• W2046276677 cites W1992068419 @default.
• W2046276677 cites W1992231742 @default.
• W2046276677 cites W1998062150 @default.
• W2046276677 cites W2002348945 @default.
• W2046276677 cites W2004098528 @default.
• W2046276677 cites W2008708467 @default.
• W2046276677 cites W2009675851 @default.
• W2046276677 cites W2010092639 @default.
• W2046276677 cites W2010511290 @default.
• W2046276677 cites W2011691446 @default.
• W2046276677 cites W2015622675 @default.
• W2046276677 cites W2016630460 @default.
• W2046276677 cites W2020399830 @default.
• W2046276677 cites W2023285934 @default.
• W2046276677 cites W2030322549 @default.
• W2046276677 cites W2033125833 @default.
• W2046276677 cites W2033975469 @default.
• W2046276677 cites W2040931022 @default.
• W2046276677 cites W2048470650 @default.
• W2046276677 cites W2057714820 @default.
• W2046276677 cites W2065864578 @default.
• W2046276677 cites W2067174909 @default.
• W2046276677 cites W2067820229 @default.
• W2046276677 cites W2068477603 @default.
• W2046276677 cites W2069123478 @default.
• W2046276677 cites W2070114315 @default.
• W2046276677 cites W2071827681 @default.
• W2046276677 cites W2073989009 @default.
• W2046276677 cites W2077313067 @default.
• W2046276677 cites W2083555454 @default.
• W2046276677 cites W2099345838 @default.
• W2046276677 cites W2106830137 @default.
• W2046276677 cites W2117118343 @default.
• W2046276677 cites W2124223881 @default.
• W2046276677 cites W2135867962 @default.
• W2046276677 cites W2144288821 @default.
• W2046276677 cites W2144481414 @default.
• W2046276677 cites W2165186407 @default.
• W2046276677 cites W2331288560 @default.
• W2046276677 cites W3104531408 @default.
• W2046276677 cites W4211192758 @default.
• W2046276677 cites W4243117937 @default.
• W2046276677 cites W4251138542 @default.
• W2046276677 doi "https://doi.org/10.1063/1.4817000" @default.
• W2046276677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23927287" @default.
• W2046276677 hasPublicationYear "2013" @default.
• W2046276677 type Work @default.
• W2046276677 sameAs 2046276677 @default.
• W2046276677 citedByCount "33" @default.
• W2046276677 countsByYear W20462766772014 @default.
• W2046276677 countsByYear W20462766772015 @default.
• W2046276677 countsByYear W20462766772016 @default.
• W2046276677 countsByYear W20462766772017 @default.
• W2046276677 countsByYear W20462766772018 @default.
• W2046276677 countsByYear W20462766772019 @default.
• W2046276677 countsByYear W20462766772020 @default.
• W2046276677 countsByYear W20462766772021 @default.
• W2046276677 countsByYear W20462766772022 @default.
• W2046276677 countsByYear W20462766772023 @default.
• W2046276677 crossrefType "journal-article" @default.
• W2046276677 hasAuthorship W2046276677A5045389074 @default.
• W2046276677 hasAuthorship W2046276677A5064842058 @default.
• W2046276677 hasAuthorship W2046276677A5066791109 @default.
• W2046276677 hasAuthorship W2046276677A5071286986 @default.
• W2046276677 hasBestOaLocation W20462766772 @default.
• W2046276677 hasConcept C112887158 @default.
• W2046276677 hasConcept C12554922 @default.
• W2046276677 hasConcept C134018914 @default.
• W2046276677 hasConcept C145148216 @default.
• W2046276677 hasConcept C147259501 @default.
• W2046276677 hasConcept C147597530 @default.
• W2046276677 hasConcept C165220095 @default.
• W2046276677 hasConcept C178790620 @default.
• W2046276677 hasConcept C179104552 @default.
• W2046276677 hasConcept C185592680 @default.
• W2046276677 hasConcept C27523624 @default.
• W2046276677 hasConcept C2777633098 @default.
• W2046276677 hasConcept C2779306644 @default.

• next