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- W2046284927 abstract "To clarify the pathogenesis of and evaluate experimental therapeutic trials for lysosomal diseases, effective tools for the detection of intracellularly accumulated materials are required.We examined a series of lectins for staining and blotting of the accumulated glycoconjugates in sialidosis and galactosialidosis.Lysosomally accumulated sialyl glycoconjugates were successfully detected in cultured fibroblasts from patients with these diseases by means of staining and blotting with Macckia amurensis (MAM).This procedure is sensitive and easy, and will be useful not only for biochemical and diagnostic analyses, but also for therapeutic evaluation in these diseases." @default.
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- W2046284927 date "2004-06-01" @default.
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- W2046284927 title "Cytochemical and biochemical detection of intracellularly accumulated sialyl glycoconjugates in sialidosis and galactosialidosis fibroblasts with Macckia amurensis" @default.
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- W2046284927 doi "https://doi.org/10.1016/j.cccn.2004.02.032" @default.
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