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• W2046285429 abstract "Phosphorylation and dephosphorylation are powerful mechanisms for the regulation of protein function including the activity of voltage-dependent ion channels. A vast body of experimental evidence exists for the regulation of cardiac ion channel activity by serine–threonine phosphorylation (for a review, see [ [1] Herzig S. Neumann J. Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. Physiol. Rev. 2000; 80: 173-210 PubMed Google Scholar ]). One of the best-known examples in cardiac physiology is the enhancement of L-type Ca2+ current upon β-adrenoceptor stimulation, that is mediated by protein kinase A (PKA)-dependent serine1928 phosphorylation of the α1C subunit of the L-type Ca2+ channel [ [2] Gao T. Yatani A. Dell'Acqua M.L. Sako H. Green S.A. Dascal N. Scott J.D. Hosey M.M. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron. 1997; 19: 185-196 Abstract Full Text Full Text PDF PubMed Scopus (434) Google Scholar ]. Activation of another serine–threonine kinase, protein kinase C, is involved, too, in enhancing L-type Ca2+ current, this kinase is activated in response to α1-adrenoceptor, endothelin or angiotensin II receptors [ [3] Kamp T.J. Hell J.W. Regulation of cardiac L-type calcium channels by protein kinase A and protein kinase C. Circ. Res. 2000; 87: 1095-1102 Crossref PubMed Scopus (495) Google Scholar ]. Voltage-dependent Na+ channels are also phosphorylated by PKA and PKC, although the functional consequences appear to be variable. A substantial body of evidence has accumulated that yet another family of kinases, protein tyrosine kinases (PTK), are involved in voltage-gated ion channel regulation (for a review, see [ [4] Davis M.J. Wu X. Nurkiewicz T.R. Kawasaki J. Gui P. Hill M.A. Wilson E. Regulation of ion channels by protein tyrosine phosphorylation. Am. J. Physiol.: Heart Circ. Physiol. 2001; 281: H1835-H1862 PubMed Google Scholar ]). These enzymes play an important role in the transduction of extracellular signals into cell proliferation, cell growth, cell adhesion and coordination of multiple cellular responses. Two large groups of protein tyrosine kinases exist: (i) the receptor PTKs include the growth factor receptors, as for instance epidermal growth factor (EGF) receptor, and (ii) the non-receptor PTKs that are found in the cytosol or the nuclei of cells. Some non-receptor PTKs are closely associated with integrins and have been considered as scaffolds for forming macromolecular complexes including ion channels." @default.
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• W2046285429 date "2007-04-01" @default.
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• W2046285429 title "Regulation of cardiac sodium channels by tyrosine kinases—Contribution to excitability?" @default.
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• W2046285429 doi "https://doi.org/10.1016/j.yjmcc.2007.01.011" @default.
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