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• W2046287762 abstract "Phenobarbital blockade of ovulation for 3 days in the proestrous hamster induces atresia of preovulatory follicles. In vitro incubations of the delayed preovulatory follicles with luteinizing hormone (LH) revealed that as the follicles approach the atretic phase (Day 3 of delay) they lose the ability to produce androstenedione (A) and estradiol (E2) but acquire the capacity to produce large quantities of progesterone (P) (Terranova, 1981b). This shift in steroidogenesis, from E2, to P, resembles those alterations in steroidogenesis during the preovulatory period in response to the LH/follicle-stimulating hormone (FSH) surge. The aim of the present study was to determine the source of P in the delayed follicle by in vitro incubation of theca and granulosa, separately, and to contrast and compare steroidogenesis of the delayed follicle with preovulatory follicles before and after the LH/FSH surge in the hamster. Incubation of theca with LH on proestrus and each day of delay (Days 1–3) revealed that theca is a primary source of follicular A and that 2–3 days of ovulatory delay induces a decline in the ability of theca to produce A in vitro. Concomitant with the decline in theca A production in vitro was an increase in thecal P production. A similar shift from A to P production by theca in vitro was observed in preovulatory follicles exposed to an endogenous LH/FSH surge. Granulosa cells from proestrous follicles (before the LH surge) and from delayed follicles did not accumulate P in vitro. However after the LH/FSH surge granulosa cells from nondelayed proestrous follicles produced large amounts of P in vitro. Granulosa cells aromatized more A to E2 on Days 1 and 2 of delay than nondelayed controls; however, by Day 3 of delay aromatizing activitywas reduced. These results indicate that theca is the major source of P in delayed follicles approaching the atretic phase; whereas in post-LH/FSH surge follicles both theca and granulosa cells produce significant quantities of P. In addition, ovulatory delay induced a significant decline in theca A production in vitro similar to that observed in preovulatory follicles after the LH/FSH surges." @default.
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• W2046287762 date "1982-05-01" @default.
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• W2046287762 title "Theca is the Source of Progesterone in Experimentally Induced Atretic Follicles of the Hamster1" @default.
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• W2046287762 doi "https://doi.org/10.1095/biolreprod26.4.721" @default.
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