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• W2046287790 endingPage "1370" @default.
• W2046287790 startingPage "1363" @default.
• W2046287790 abstract "Conditioning theories propose that, through a Pavlovian associative process, discrete stimuli acquire the ability to elicit neural states involved in the maintenance and relapse of a drug-taking behaviour. Experimental evidence indicates that drug-related cues play a role in relapse, however, their influence on the development and maintenance of drug self-administration has been poorly investigated. In this report, we analysed the effects of a drug-associated cue light on acquisition, maintenance and reinstatement of intravenous cocaine self-administration. The results show that a cocaine-associated cue light can act as an incentive in absence of the drug, but does not directly modify drug-reinforcing effects. Contingent and non-contingent presentations of a cocaine-associated cue light reinstated an extinguished self-administration behaviour. However, regardless of whether or not a cue light was associated with cocaine infusions, rats acquire cocaine intravenous self-administration reaching the same levels of intake. Furthermore, after self-administration has been acquired in presence of the cue light, the omission of the cue light or its non-contingent presentation did not modify rat behaviour. In conclusion, our work shows that cocaine-associated explicit cues do not directly interfere with the reinforcing effects of the drug." @default.
• W2046287790 created "2016-06-24" @default.
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• W2046287790 date "2002-04-01" @default.
• W2046287790 modified "2023-10-14" @default.
• W2046287790 title "Influence of cue-conditioning on acquisition, maintenance and relapse of cocaine intravenous self-administration" @default.
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• W2046287790 doi "https://doi.org/10.1046/j.1460-9568.2002.01974.x" @default.
• W2046287790 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11994130" @default.
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