FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046287986> ?p ?o ?g. }

• W2046287986 endingPage "10" @default.
• W2046287986 startingPage "1" @default.
• W2046287986 abstract "Ca2+-dependent CaMKIIα activation with autophosphorylation plays an essential role in learning and memory. The regulation of CaMKIIα by dephosphorylation by protein phosphatase 1 (PP1) has been demonstrated. We addressed whether the protein phosphatase 2A (PP2A) that is abundant in the brain could be involved in the regulation of CaMKIIα. CaMKIIα was associated with the catalytic subunit of PP2A (PP2Ac) and α4, a regulator of PP2A. To investigate whether α4 plays an important role in the CNS, we established a neuron specific Cre transgenic mouse and a neuron specific α4 deficient mouse (N-α4 KO mouse). This N-α4 KO mouse showed impaired learning and memory in a water maze and also shuttle-box avoidance test. The activity of CaMKIIα also increased in hippocampus. An overexpression of α4 in the neuronal cell line demonstrated the activity of CaMKIIα to be regulated by α4. α4 and PP2Ac were localized in the cytoplasm but not in the postsynaptic density (PSD), thus suggesting that the dephosphorylation of CaMKIIα by α4/PP2Ac occurred in the cytoplasm. These results suggest that α4 and PP2A may thus play an important role in CaMKIIα regulation and thereby also influence learning." @default.
• W2046287986 created "2016-06-24" @default.
• W2046287986 creator A5022174211 @default.
• W2046287986 creator A5037220014 @default.
• W2046287986 creator A5055184036 @default.
• W2046287986 creator A5055199667 @default.
• W2046287986 creator A5055983723 @default.
• W2046287986 creator A5066304083 @default.
• W2046287986 creator A5085726790 @default.
• W2046287986 date "2006-04-01" @default.
• W2046287986 modified "2023-10-17" @default.
• W2046287986 title "Regulation of CaMKII by α4/PP2Ac contributes to learning and memory" @default.
• W2046287986 cites W1597917646 @default.
• W2046287986 cites W1598704961 @default.
• W2046287986 cites W1598855117 @default.
• W2046287986 cites W1602481380 @default.
• W2046287986 cites W1892570697 @default.
• W2046287986 cites W1977840142 @default.
• W2046287986 cites W1990049897 @default.
• W2046287986 cites W2009698873 @default.
• W2046287986 cites W2019996886 @default.
• W2046287986 cites W2021235911 @default.
• W2046287986 cites W2021885593 @default.
• W2046287986 cites W2028125810 @default.
• W2046287986 cites W2032619952 @default.
• W2046287986 cites W2035831063 @default.
• W2046287986 cites W2054975255 @default.
• W2046287986 cites W2064007974 @default.
• W2046287986 cites W2072087613 @default.
• W2046287986 cites W2106389606 @default.
• W2046287986 cites W2113545093 @default.
• W2046287986 cites W2129737994 @default.
• W2046287986 cites W2131972962 @default.
• W2046287986 cites W2137221055 @default.
• W2046287986 cites W2144838091 @default.
• W2046287986 cites W2149369543 @default.
• W2046287986 cites W2178456244 @default.
• W2046287986 cites W2288796536 @default.
• W2046287986 cites W4240253200 @default.
• W2046287986 cites W4241770029 @default.
• W2046287986 cites W4361744781 @default.
• W2046287986 doi "https://doi.org/10.1016/j.brainres.2006.01.101" @default.
• W2046287986 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16516168" @default.
• W2046287986 hasPublicationYear "2006" @default.
• W2046287986 type Work @default.
• W2046287986 sameAs 2046287986 @default.
• W2046287986 citedByCount "42" @default.
• W2046287986 countsByYear W20462879862012 @default.
• W2046287986 countsByYear W20462879862013 @default.
• W2046287986 countsByYear W20462879862014 @default.
• W2046287986 countsByYear W20462879862015 @default.
• W2046287986 countsByYear W20462879862016 @default.
• W2046287986 countsByYear W20462879862018 @default.
• W2046287986 countsByYear W20462879862019 @default.
• W2046287986 countsByYear W20462879862021 @default.
• W2046287986 countsByYear W20462879862022 @default.
• W2046287986 countsByYear W20462879862023 @default.
• W2046287986 crossrefType "journal-article" @default.
• W2046287986 hasAuthorship W2046287986A5022174211 @default.
• W2046287986 hasAuthorship W2046287986A5037220014 @default.
• W2046287986 hasAuthorship W2046287986A5055184036 @default.
• W2046287986 hasAuthorship W2046287986A5055199667 @default.
• W2046287986 hasAuthorship W2046287986A5055983723 @default.
• W2046287986 hasAuthorship W2046287986A5066304083 @default.
• W2046287986 hasAuthorship W2046287986A5085726790 @default.
• W2046287986 hasConcept C102230213 @default.
• W2046287986 hasConcept C104292427 @default.
• W2046287986 hasConcept C104317684 @default.
• W2046287986 hasConcept C11960822 @default.
• W2046287986 hasConcept C141035611 @default.
• W2046287986 hasConcept C150109051 @default.
• W2046287986 hasConcept C169760540 @default.
• W2046287986 hasConcept C178666793 @default.
• W2046287986 hasConcept C181912034 @default.
• W2046287986 hasConcept C185592680 @default.
• W2046287986 hasConcept C190062978 @default.
• W2046287986 hasConcept C2778794669 @default.
• W2046287986 hasConcept C2781161787 @default.
• W2046287986 hasConcept C389152 @default.
• W2046287986 hasConcept C55493867 @default.
• W2046287986 hasConcept C86803240 @default.
• W2046287986 hasConcept C95444343 @default.
• W2046287986 hasConcept C97029542 @default.
• W2046287986 hasConceptScore W2046287986C102230213 @default.
• W2046287986 hasConceptScore W2046287986C104292427 @default.
• W2046287986 hasConceptScore W2046287986C104317684 @default.
• W2046287986 hasConceptScore W2046287986C11960822 @default.
• W2046287986 hasConceptScore W2046287986C141035611 @default.
• W2046287986 hasConceptScore W2046287986C150109051 @default.
• W2046287986 hasConceptScore W2046287986C169760540 @default.
• W2046287986 hasConceptScore W2046287986C178666793 @default.
• W2046287986 hasConceptScore W2046287986C181912034 @default.
• W2046287986 hasConceptScore W2046287986C185592680 @default.
• W2046287986 hasConceptScore W2046287986C190062978 @default.
• W2046287986 hasConceptScore W2046287986C2778794669 @default.
• W2046287986 hasConceptScore W2046287986C2781161787 @default.
• W2046287986 hasConceptScore W2046287986C389152 @default.
• W2046287986 hasConceptScore W2046287986C55493867 @default.

• next