FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046291010> ?p ?o ?g. }

• W2046291010 endingPage "57" @default.
• W2046291010 startingPage "48" @default.
• W2046291010 abstract "The present study aimed to elucidate visual evoked potentials (VEP) changes in MPTP induced Parkinson’s disease (PD) and investigate the possible benefical effects of neuronal (n) and inducible (i) nitric oxide synthase (NOS) inhibitors on altered VEPs, lipid peroxidation and apoptosis. 3 months old C57BL/6 mice were randomly divided into 6 groups which included control (C), 7-nitra indazole treated (7-NI), S-methylisothiourea (SMT) treated, 1,2,3,6-tetrahydropyridine (MPTP) treated, 7-NI + MPTP treated and SMT + MPTP treated. Motor activity of mice was evaluated via the pole test. At the end of the experimental period VEPs were recorded, brain and retina tissues were removed for biochemical analysis. Dopaminergic neuron death at substantia nigra (SN) was determined by immunohistochemical analysis of tyrosine hydroxylase (TH). Immunohistochemical staining was also performed to determine iNOS and nNOS in all tissue sections. Mice with experimental PD exhibited decreased motor activity. Dopaminergic cell death at pars compacta of SN (SNpc) was significantly increased in MPTP treated group compared to control. Diminished Parkinsonism symptoms were observed in 7-NI + MPTP and SMT + MPTP groups. Treatment with 7-NI and SMT decreased dopaminergic cell death in MPTP treated mice. Caspase-3 activity, nitrite/nitrate and 4-hydroxynonenal (4-HNE) levels were significantly increased in SN of MPTP treated mice compared to control. Treatment with 7-NI and SMT significantly decreased elevated caspase-3 activity, nitrite/nitrate and 4-HNE levels in SN of MPTP treated mice. No significant difference in above parameters were observed in the retina. VEP latencies were significantly prolonged in MPTP group compared to control group. 7-NI and SMT treatment caused a significant decrease in VEP latencies in MPTP treated mice compared to none treated MPTP group. This data shows that 7-NI and SMT improves prolonged VEP latencies. The protective effects of 7-NI and SMT on VEP alterations can be related to decreased dopaminergic cell death and reduced lipid peroxidation." @default.
• W2046291010 created "2016-06-24" @default.
• W2046291010 creator A5002745410 @default.
• W2046291010 creator A5037756638 @default.
• W2046291010 creator A5061485726 @default.
• W2046291010 creator A5068460460 @default.
• W2046291010 creator A5071178019 @default.
• W2046291010 date "2014-06-01" @default.
• W2046291010 modified "2023-10-18" @default.
• W2046291010 title "The role of nitric oxide on visual-evoked potentials in MPTP-induced Parkinsonism in mice" @default.
• W2046291010 cites W1635791860 @default.
• W2046291010 cites W1964671322 @default.
• W2046291010 cites W1973791051 @default.
• W2046291010 cites W1979404773 @default.
• W2046291010 cites W1979710783 @default.
• W2046291010 cites W1980218995 @default.
• W2046291010 cites W1982367147 @default.
• W2046291010 cites W1993250284 @default.
• W2046291010 cites W2000531132 @default.
• W2046291010 cites W2004521377 @default.
• W2046291010 cites W2005333768 @default.
• W2046291010 cites W2006306666 @default.
• W2046291010 cites W2015255727 @default.
• W2046291010 cites W2017320893 @default.
• W2046291010 cites W2019421902 @default.
• W2046291010 cites W2019512435 @default.
• W2046291010 cites W2020023994 @default.
• W2046291010 cites W2025348767 @default.
• W2046291010 cites W2027459042 @default.
• W2046291010 cites W2027565503 @default.
• W2046291010 cites W2031489450 @default.
• W2046291010 cites W2033810507 @default.
• W2046291010 cites W2033880803 @default.
• W2046291010 cites W2034245376 @default.
• W2046291010 cites W2034813650 @default.
• W2046291010 cites W2036876722 @default.
• W2046291010 cites W2037137402 @default.
• W2046291010 cites W2038814798 @default.
• W2046291010 cites W2041766154 @default.
• W2046291010 cites W2045465871 @default.
• W2046291010 cites W2047358908 @default.
• W2046291010 cites W2048111111 @default.
• W2046291010 cites W2048570076 @default.
• W2046291010 cites W2049249821 @default.
• W2046291010 cites W2051333776 @default.
• W2046291010 cites W2071862060 @default.
• W2046291010 cites W2076975822 @default.
• W2046291010 cites W2077673872 @default.
• W2046291010 cites W2092871886 @default.
• W2046291010 cites W2094737647 @default.
• W2046291010 cites W2095312480 @default.
• W2046291010 cites W2103738800 @default.
• W2046291010 cites W2123684032 @default.
• W2046291010 cites W2128803223 @default.
• W2046291010 cites W2138379089 @default.
• W2046291010 cites W2138566001 @default.
• W2046291010 cites W2148440235 @default.
• W2046291010 cites W2148623334 @default.
• W2046291010 cites W24021922 @default.
• W2046291010 doi "https://doi.org/10.1016/j.neuint.2014.04.014" @default.
• W2046291010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24795109" @default.
• W2046291010 hasPublicationYear "2014" @default.
• W2046291010 type Work @default.
• W2046291010 sameAs 2046291010 @default.
• W2046291010 citedByCount "25" @default.
• W2046291010 countsByYear W20462910102014 @default.
• W2046291010 countsByYear W20462910102015 @default.
• W2046291010 countsByYear W20462910102016 @default.
• W2046291010 countsByYear W20462910102017 @default.
• W2046291010 countsByYear W20462910102019 @default.
• W2046291010 countsByYear W20462910102020 @default.
• W2046291010 countsByYear W20462910102021 @default.
• W2046291010 countsByYear W20462910102022 @default.
• W2046291010 countsByYear W20462910102023 @default.
• W2046291010 crossrefType "journal-article" @default.
• W2046291010 hasAuthorship W2046291010A5002745410 @default.
• W2046291010 hasAuthorship W2046291010A5037756638 @default.
• W2046291010 hasAuthorship W2046291010A5061485726 @default.
• W2046291010 hasAuthorship W2046291010A5068460460 @default.
• W2046291010 hasAuthorship W2046291010A5071178019 @default.
• W2046291010 hasConcept C126322002 @default.
• W2046291010 hasConcept C134018914 @default.
• W2046291010 hasConcept C137183658 @default.
• W2046291010 hasConcept C159167319 @default.
• W2046291010 hasConcept C185592680 @default.
• W2046291010 hasConcept C2776525014 @default.
• W2046291010 hasConcept C2776773494 @default.
• W2046291010 hasConcept C2777622882 @default.
• W2046291010 hasConcept C2778674702 @default.
• W2046291010 hasConcept C2779134260 @default.
• W2046291010 hasConcept C2779734285 @default.
• W2046291010 hasConcept C2780358027 @default.
• W2046291010 hasConcept C2780938664 @default.
• W2046291010 hasConcept C513476851 @default.
• W2046291010 hasConcept C519581460 @default.
• W2046291010 hasConcept C71924100 @default.
• W2046291010 hasConcept C98274493 @default.
• W2046291010 hasConceptScore W2046291010C126322002 @default.

• next