FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046291279> ?p ?o ?g. }

• W2046291279 endingPage "293" @default.
• W2046291279 startingPage "284" @default.
• W2046291279 abstract "Objective: Impaired systolic function in the normally perfused myocardium adjacent to an ischemic region — the functional border zone — is thought to result from mechanical interactions across the perfusion boundary. We investigated how segment orientation and vessel involved affect regional strains in the functional border zone and whether altered stresses associated with a step transition in contractility can explain the functional border zone. Methods and results: Regional epicardial strain distributions were obtained from measured displacements of radiopaque markers in open-chest anesthetized canines, and related to local myofiber angles and blood flows. The functional border zone for fiber strain was significantly narrower than that for cross-fiber strain and significantly wider for left anterior descending (LAD) than left circumflex (LCx) coronary occlusion (1.23 vs. 0.45 cm). A detailed three-dimensional computational model with a one-to-one relation between perfusion and myofilament activation and no transitional zone of intermediate contractility showed close agreement with these observations and significantly elevated stresses in the border zone. Differences between LAD and LCx occlusions in the model were due to differences in left ventricular systolic pressure and not to differences in perfusion boundary or muscle fiber orientation. The border zone was narrower for fiber strain than cross-fiber strain because systolic stiffness is greatest along the muscle fiber direction. Conclusion: Abnormal regional mechanics in the acute ischemic border arise from increased wall stresses without a transitional zone of intermediate contractility. Perfusion is more tightly coupled to fiber than cross-fiber strain, and a wider functional border zone of fiber strain during LAD than LCx occlusion is primarily due to higher regional wall stresses rather than anatomic variations." @default.
• W2046291279 created "2016-06-24" @default.
• W2046291279 creator A5013532679 @default.
• W2046291279 creator A5033811596 @default.
• W2046291279 creator A5044195613 @default.
• W2046291279 creator A5077052779 @default.
• W2046291279 date "2000-08-01" @default.
• W2046291279 modified "2023-10-16" @default.
• W2046291279 title "Structural basis of regional dysfunction in acutely ischemic myocardium" @default.
• W2046291279 cites W105146696 @default.
• W2046291279 cites W184496896 @default.
• W2046291279 cites W1885774346 @default.
• W2046291279 cites W1986005020 @default.
• W2046291279 cites W1995253526 @default.
• W2046291279 cites W2000761891 @default.
• W2046291279 cites W2007983979 @default.
• W2046291279 cites W2016810115 @default.
• W2046291279 cites W2018136145 @default.
• W2046291279 cites W2036598770 @default.
• W2046291279 cites W2084421529 @default.
• W2046291279 cites W2085761954 @default.
• W2046291279 cites W2086927972 @default.
• W2046291279 cites W2097874869 @default.
• W2046291279 cites W2105279343 @default.
• W2046291279 cites W2112537235 @default.
• W2046291279 cites W2130432285 @default.
• W2046291279 cites W2135926315 @default.
• W2046291279 cites W2142333871 @default.
• W2046291279 cites W2154321684 @default.
• W2046291279 cites W2161629941 @default.
• W2046291279 cites W2162098060 @default.
• W2046291279 cites W2166919594 @default.
• W2046291279 cites W2181273021 @default.
• W2046291279 cites W2226886427 @default.
• W2046291279 cites W2266826025 @default.
• W2046291279 cites W2944810619 @default.
• W2046291279 cites W2971244461 @default.
• W2046291279 cites W3140501017 @default.
• W2046291279 doi "https://doi.org/10.1016/s0008-6363(00)00089-4" @default.
• W2046291279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10946065" @default.
• W2046291279 hasPublicationYear "2000" @default.
• W2046291279 type Work @default.
• W2046291279 sameAs 2046291279 @default.
• W2046291279 citedByCount "62" @default.
• W2046291279 countsByYear W20462912792012 @default.
• W2046291279 countsByYear W20462912792013 @default.
• W2046291279 countsByYear W20462912792015 @default.
• W2046291279 countsByYear W20462912792016 @default.
• W2046291279 countsByYear W20462912792017 @default.
• W2046291279 countsByYear W20462912792018 @default.
• W2046291279 countsByYear W20462912792019 @default.
• W2046291279 countsByYear W20462912792020 @default.
• W2046291279 countsByYear W20462912792021 @default.
• W2046291279 countsByYear W20462912792022 @default.
• W2046291279 countsByYear W20462912792023 @default.
• W2046291279 crossrefType "journal-article" @default.
• W2046291279 hasAuthorship W2046291279A5013532679 @default.
• W2046291279 hasAuthorship W2046291279A5033811596 @default.
• W2046291279 hasAuthorship W2046291279A5044195613 @default.
• W2046291279 hasAuthorship W2046291279A5077052779 @default.
• W2046291279 hasBestOaLocation W20462912791 @default.
• W2046291279 hasConcept C105702510 @default.
• W2046291279 hasConcept C126322002 @default.
• W2046291279 hasConcept C146957229 @default.
• W2046291279 hasConcept C164705383 @default.
• W2046291279 hasConcept C174054327 @default.
• W2046291279 hasConcept C197321550 @default.
• W2046291279 hasConcept C207200792 @default.
• W2046291279 hasConcept C2776268601 @default.
• W2046291279 hasConcept C2776820930 @default.
• W2046291279 hasConcept C2778022156 @default.
• W2046291279 hasConcept C2779096242 @default.
• W2046291279 hasConcept C39133596 @default.
• W2046291279 hasConcept C500558357 @default.
• W2046291279 hasConcept C71924100 @default.
• W2046291279 hasConceptScore W2046291279C105702510 @default.
• W2046291279 hasConceptScore W2046291279C126322002 @default.
• W2046291279 hasConceptScore W2046291279C146957229 @default.
• W2046291279 hasConceptScore W2046291279C164705383 @default.
• W2046291279 hasConceptScore W2046291279C174054327 @default.
• W2046291279 hasConceptScore W2046291279C197321550 @default.
• W2046291279 hasConceptScore W2046291279C207200792 @default.
• W2046291279 hasConceptScore W2046291279C2776268601 @default.
• W2046291279 hasConceptScore W2046291279C2776820930 @default.
• W2046291279 hasConceptScore W2046291279C2778022156 @default.
• W2046291279 hasConceptScore W2046291279C2779096242 @default.
• W2046291279 hasConceptScore W2046291279C39133596 @default.
• W2046291279 hasConceptScore W2046291279C500558357 @default.
• W2046291279 hasConceptScore W2046291279C71924100 @default.
• W2046291279 hasIssue "2" @default.
• W2046291279 hasLocation W20462912791 @default.
• W2046291279 hasLocation W20462912792 @default.
• W2046291279 hasOpenAccess W2046291279 @default.
• W2046291279 hasPrimaryLocation W20462912791 @default.
• W2046291279 hasRelatedWork W1990395476 @default.
• W2046291279 hasRelatedWork W1994434426 @default.
• W2046291279 hasRelatedWork W2022920476 @default.
• W2046291279 hasRelatedWork W2023841582 @default.

• next