Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046293625> ?p ?o ?g. }
- W2046293625 endingPage "691" @default.
- W2046293625 startingPage "686" @default.
- W2046293625 abstract "Tetrandrine (TET) is a bis-benzylisoquinoline alkaloid derived from the radix of Stephania tetrandra S. Moore. TET performs a wide spectrum of biological activities. The radix of S. tetrandrae has been used traditionally in Asia, including Korea, to treat congestive circulatory disorders and inflammatory diseases. The aim of this study was to examine the mechanism of antibacterial activity of tetrandrine against Staphylococcus aureus. The mechanism was investigated by studying the effects of TET in combination with detergent or membrane potential un-couplers. In addition, the direct involvement of peptidoglycan (PGN) was assessed in titration assays. TET activity against S. aureus was 125–250 μg/mL, and the minimum inhibitory concentration (MIC) of the two reference strains was 250 μg/mL. The OD600 of each suspension treated with a combination of ethylenediaminetetraacetic acid (EDTA), tris(hydroxymethyl) aminomethane (TRIS), and Triton X-100 (TX) with TET (0.25×MIC) had been reduced from 43% to 96%. Additional structure-function studies on the antibacterialactivity of TET in combination with other agents may lead to the discovery of more effective antibacterial agents." @default.
- W2046293625 created "2016-06-24" @default.
- W2046293625 creator A5021150103 @default.
- W2046293625 creator A5023175759 @default.
- W2046293625 creator A5026459010 @default.
- W2046293625 creator A5027852869 @default.
- W2046293625 creator A5035156295 @default.
- W2046293625 creator A5040232770 @default.
- W2046293625 creator A5056758385 @default.
- W2046293625 creator A5061178178 @default.
- W2046293625 creator A5075341821 @default.
- W2046293625 creator A5076186951 @default.
- W2046293625 creator A5082406342 @default.
- W2046293625 creator A5091398128 @default.
- W2046293625 date "2012-08-01" @default.
- W2046293625 modified "2023-09-26" @default.
- W2046293625 title "The Mechanism of Antibacterial Activity of Tetrandrine Against<i>Staphylococcus aureus</i>" @default.
- W2046293625 cites W104451405 @default.
- W2046293625 cites W1484446060 @default.
- W2046293625 cites W1522634478 @default.
- W2046293625 cites W1550532992 @default.
- W2046293625 cites W1966750278 @default.
- W2046293625 cites W1971333569 @default.
- W2046293625 cites W1980249129 @default.
- W2046293625 cites W1989165540 @default.
- W2046293625 cites W1996240576 @default.
- W2046293625 cites W2006605582 @default.
- W2046293625 cites W2007236728 @default.
- W2046293625 cites W2008212732 @default.
- W2046293625 cites W2022952065 @default.
- W2046293625 cites W2036104262 @default.
- W2046293625 cites W2053886251 @default.
- W2046293625 cites W2057166192 @default.
- W2046293625 cites W2065790283 @default.
- W2046293625 cites W2088893373 @default.
- W2046293625 cites W2092266299 @default.
- W2046293625 cites W2092487495 @default.
- W2046293625 cites W2099883798 @default.
- W2046293625 cites W2100596948 @default.
- W2046293625 cites W2105789943 @default.
- W2046293625 cites W2115590616 @default.
- W2046293625 cites W2139772204 @default.
- W2046293625 cites W2152206417 @default.
- W2046293625 cites W2314649741 @default.
- W2046293625 cites W940824992 @default.
- W2046293625 doi "https://doi.org/10.1089/fpd.2011.1119" @default.
- W2046293625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22845553" @default.
- W2046293625 hasPublicationYear "2012" @default.
- W2046293625 type Work @default.
- W2046293625 sameAs 2046293625 @default.
- W2046293625 citedByCount "21" @default.
- W2046293625 countsByYear W20462936252014 @default.
- W2046293625 countsByYear W20462936252015 @default.
- W2046293625 countsByYear W20462936252016 @default.
- W2046293625 countsByYear W20462936252018 @default.
- W2046293625 countsByYear W20462936252020 @default.
- W2046293625 countsByYear W20462936252021 @default.
- W2046293625 countsByYear W20462936252022 @default.
- W2046293625 countsByYear W20462936252023 @default.
- W2046293625 crossrefType "journal-article" @default.
- W2046293625 hasAuthorship W2046293625A5021150103 @default.
- W2046293625 hasAuthorship W2046293625A5023175759 @default.
- W2046293625 hasAuthorship W2046293625A5026459010 @default.
- W2046293625 hasAuthorship W2046293625A5027852869 @default.
- W2046293625 hasAuthorship W2046293625A5035156295 @default.
- W2046293625 hasAuthorship W2046293625A5040232770 @default.
- W2046293625 hasAuthorship W2046293625A5056758385 @default.
- W2046293625 hasAuthorship W2046293625A5061178178 @default.
- W2046293625 hasAuthorship W2046293625A5075341821 @default.
- W2046293625 hasAuthorship W2046293625A5076186951 @default.
- W2046293625 hasAuthorship W2046293625A5082406342 @default.
- W2046293625 hasAuthorship W2046293625A5091398128 @default.
- W2046293625 hasConcept C176947019 @default.
- W2046293625 hasConcept C178790620 @default.
- W2046293625 hasConcept C185592680 @default.
- W2046293625 hasConcept C197404232 @default.
- W2046293625 hasConcept C2778973965 @default.
- W2046293625 hasConcept C2779489039 @default.
- W2046293625 hasConcept C2779934757 @default.
- W2046293625 hasConcept C2780104969 @default.
- W2046293625 hasConcept C2780591741 @default.
- W2046293625 hasConcept C4937899 @default.
- W2046293625 hasConcept C523546767 @default.
- W2046293625 hasConcept C54355233 @default.
- W2046293625 hasConcept C71240020 @default.
- W2046293625 hasConcept C71924100 @default.
- W2046293625 hasConcept C86803240 @default.
- W2046293625 hasConcept C89423630 @default.
- W2046293625 hasConcept C98274493 @default.
- W2046293625 hasConceptScore W2046293625C176947019 @default.
- W2046293625 hasConceptScore W2046293625C178790620 @default.
- W2046293625 hasConceptScore W2046293625C185592680 @default.
- W2046293625 hasConceptScore W2046293625C197404232 @default.
- W2046293625 hasConceptScore W2046293625C2778973965 @default.
- W2046293625 hasConceptScore W2046293625C2779489039 @default.
- W2046293625 hasConceptScore W2046293625C2779934757 @default.
- W2046293625 hasConceptScore W2046293625C2780104969 @default.
- W2046293625 hasConceptScore W2046293625C2780591741 @default.