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- W2046296412 endingPage "28" @default.
- W2046296412 startingPage "18" @default.
- W2046296412 abstract "Converging evidence indicates that processes occurring in and around neuronal dendrites are central to the pathogenesis of Alzheimer's disease. These data support the concept of a dendritic hypothesis of AD, closely related to the existing synaptic hypothesis. Here we detail dendritic neuropathology in the disease and examine how Aβ, tau, and AD genetic risk factors affect dendritic structure and function. Finally, we consider potential mechanisms by which these key drivers could affect dendritic integrity and disease progression. These dendritic mechanisms serve as a framework for therapeutic target identification and for efforts to develop disease-modifying therapeutics for Alzheimer's disease." @default.
- W2046296412 created "2016-06-24" @default.
- W2046296412 creator A5026622056 @default.
- W2046296412 creator A5050131014 @default.
- W2046296412 creator A5055043813 @default.
- W2046296412 date "2014-04-01" @default.
- W2046296412 modified "2023-10-02" @default.
- W2046296412 title "The dendritic hypothesis for Alzheimer's disease pathophysiology" @default.
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