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- W2046297621 abstract "The response of metabolic variables to small rate changes is quantitatively described by the control coefficients (Kacser & Burns, 1973; Heinrich & Rapoport, 1974). Owing to the existence of structural and kinetic constraints in metabolism, the control coefficients are not all independent. Two quantities are defined to evaluate how constrained metabolic control is: the fraction of independent control coefficients ( f w ) and the number of independent control coefficients per independent variable [ N ( C / V )]. It is shown that f w can be expressed in terms of the fraction of independent metabolite concentrations, the fraction of independent fluxes and the average fraction of independent metabolites affecting each rate. N ( C / V ) is equal to the average number of metabolite concentrations affecting each rate. The estimation of these quantities using experimental information available leads to the following conclusions concerning cellular metabolism: (i) only a small fraction of the control coefficients are independent; (ii) the number of rates (in average) that independently controls each independent variable is much smaller than its theoretical maximum; and (iii) the kinetic constraints are the main cause of the low value showed by f w and N ( C / V ). Finally, some arguments are given, that could explain why living organisms do not evolve to less constrained metabolic responses." @default.
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- W2046297621 date "1996-10-01" @default.
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- W2046297621 title "How Constrained is Metabolic Control?" @default.
- W2046297621 doi "https://doi.org/10.1006/jtbi.1996.0165" @default.
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