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• W2046306695 abstract "Synthetic molecules that target specific lipids serve as powerful tools for understanding membrane biology and may also enable new applications in biotechnology and medicine. For example, selective recognition of bacterial lipids may give rise to novel antibiotics, as well as diagnostic methods for bacterial infection. Currently known lipid-binding molecules primarily rely on noncovalent interactions to achieve lipid selectivity. Here we show that targeted recognition of lipids can be realized by selectively modifying the lipid of interest via covalent bond formation. Specifically, we report an unnatural amino acid that preferentially labels amine-presenting lipids via iminoboronate formation under physiological conditions. By targeting phosphatidylethanolamine and lysylphosphatidylglycerol, the two lipids enriched on bacterial cell surfaces, the iminoboronate chemistry allows potent labelling of Gram-positive bacteria even in the presence of 10% serum, while bypassing mammalian cells and Gram-negative bacteria. The covalent strategy for lipid recognition should be extendable to other important membrane lipids. The analysis of cell membrane biology, and in particular the constituent lipid content, can yield important information on cell function. Here, the authors present a method to selectively and covalently label amine-presenting lipids in bacterial cell membranes." @default.
• W2046306695 created "2016-06-24" @default.
• W2046306695 creator A5047251687 @default.
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• W2046306695 date "2015-03-12" @default.
• W2046306695 modified "2023-10-02" @default.
• W2046306695 title "Targeting bacteria via iminoboronate chemistry of amine-presenting lipids" @default.
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• W2046306695 doi "https://doi.org/10.1038/ncomms7561" @default.
• W2046306695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4363082" @default.
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