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- W2046308032 endingPage "506" @default.
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- W2046308032 abstract "The ovary is a dynamic organ that undergoes cyclic structural and functional changes. Structurally, the internal architecture of the ovary constantly changes as follicles grow, rupture and transform into corpora lutea in a cyclical manner. Functionally, a variety of regulatory ovarian hormones are sequentially produced, and eggs are periodically released. As a highly vascularized organ, the ovarian structures and functions change in response to external stimuli that include but are not limited to pituitary gonadotropins. Following stimulation, the ovary synthesizes and releases autocrine and paracrine signals that play unique roles in regulating its function. Recent studies have identified endothelins as local regulators in the ovary that modulate multiple cyclic events, such as follicle growth, steroidogenesis, oocyte maturation, ovulation, corpus luteum formation and luteolysis. Interestingly, in all mammalian species examined to date, a common observation has been made: the ovary produces two pharmacologically similar endothelins (ET-1 and ET-2) but expresses two functionally different endothelin receptors (ET(A) and ET(B)) that often give rise to opposite physiological outcomes following activation by an endothelin. In this review, the physiological significance of the presence of the two ligand-two receptor endothelin system in the ovary will be discussed." @default.
- W2046308032 created "2016-06-24" @default.
- W2046308032 creator A5017221653 @default.
- W2046308032 creator A5049931844 @default.
- W2046308032 creator A5081664492 @default.
- W2046308032 date "2012-10-01" @default.
- W2046308032 modified "2023-09-26" @default.
- W2046308032 title "Why two endothelins and two receptors for ovulation and luteal regulation?" @default.
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- W2046308032 doi "https://doi.org/10.1016/j.lfs.2012.05.010" @default.
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