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- W2046320010 abstract "Previous research has demonstrated that numerous populations of immune cell, including lymphocytes, synthesize nociceptin (N/OFQ) precursor mRNA although little is known regarding the immunological role of N/OFQ. In the present study we have demonstrated significant effects of mitogens, pro-inflammatory cytokines, cyclic AMP analogues, glucocorticoids and CRF on N/OFQ secretion by rat splenocytes in vitro. N/OFQ (10−14 to 10−10 M) was also shown to inhibit proliferation of Con A-activated splenocytes and production of IL-2 in vitro. In summary we have shown how a variety of stimuli relevant to inflammation can regulate endogenous N/OFQ secretion by splenocytes in vitro. We also suggest that N/OFQ may promote anti-inflammatory actions via suppression of IL-2 in vivo." @default.
- W2046320010 created "2016-06-24" @default.
- W2046320010 creator A5074463122 @default.
- W2046320010 creator A5077257635 @default.
- W2046320010 date "2007-11-01" @default.
- W2046320010 modified "2023-10-04" @default.
- W2046320010 title "Regulation of nociceptin/orphaninFQ secretion by immune cells and functional modulation of interleukin-2" @default.
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- W2046320010 doi "https://doi.org/10.1016/j.peptides.2007.09.004" @default.
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