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- W2046328704 endingPage "1088" @default.
- W2046328704 startingPage "1077" @default.
- W2046328704 abstract "Polytopic α-helical membrane proteins cannot spontaneously insert into lipid bilayers without assistance from polytopic α-helical membrane proteins that already reside in the membrane. This raises the question of how these proteins evolved. Our current knowledge of the insertion of α-helices into natural and model membranes is reviewed with the goal of gaining insight into the evolution of membrane proteins. Topics include: translocon-dependent membrane protein insertion, antibiotic peptides and proteins, in vitro insertion of membrane proteins, chaperone-mediated insertion of transmembrane helices, and C-terminal tail-anchored (TA) proteins. Analysis of the E. coli genome reveals several predicted C-terminal TA proteins that may be descendents of proteins involved in pre-cellular membrane protein insertion. Mechanisms of pre-translocon polytopic α-helical membrane protein insertion are discussed." @default.
- W2046328704 created "2016-06-24" @default.
- W2046328704 creator A5075836765 @default.
- W2046328704 date "2009-12-29" @default.
- W2046328704 modified "2023-10-17" @default.
- W2046328704 title "Helix insertion into bilayers and the evolution of membrane proteins" @default.
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- W2046328704 doi "https://doi.org/10.1007/s00018-009-0234-9" @default.
- W2046328704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2862650" @default.
- W2046328704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20039094" @default.
- W2046328704 hasPublicationYear "2009" @default.