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- W2046330183 abstract "Summary. Mouse embryos recovered on the 4th day of pregnancy produced histamine, as evidenced by the14CO2 produced from carboxy labelled l-histidine, at the rate of 1·5 ± 0·3 (s.e.m.) pmol/embryo per hour. Most (83·2 ± 4·6%) of the embryos flushed from the oviducts on Day 3 of pregnancy (4–8-cell stage) developed into blastocysts within 48 h after being placed in culture. Inclusion of l-histidine hydrochloride (4·7 × 10−4 m) in the culture medium did not alter this development but dl-α-methylhistidine (3·8 × 10−4 m), an inhibitor of histidine decarboxylase, reduced the number of embryos developing into blastocysts to only 10·8 ± 6·8%. A combination of l-histidine and dl-α-methylhistidine in the medium prevented the growth-retarding effect of the latter compound. The results indicate that mouse embryos can produce histamine and suggest that this is necessary for normal development." @default.
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- W2046330183 title "Histamine formation by mouse preimplantation embryos" @default.
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- W2046330183 doi "https://doi.org/10.1530/jrf.0.0600457" @default.
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