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- W2046334580 abstract "Background . Levosimendan is an inotropic drug with unique pharmacological advantages in patients with acute heart failure. Scope of this study is to determine whether longer infusion patterns without the hypotension-inducing loading dose could justify an effective and safe alternative approach. Methods . 70 patients admitted to the emergencies with decompensated chronic heart failure received intravenously levosimendan without a loading dose up to 72 hours. Clinical parameters, BNP (Brain Natriuretic Peptide) and signal-averaged-ECG data (SAECG) were recorded up to 72 hours. Results . The 48-hour group demonstrated a statistically significant BNP decrease (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.001</mml:mn></mml:math>) after 48 hours, which also maintained after 72 hours. The 72-hour group demonstrated a bordeline decrease of BNP after 48 hours (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.039</mml:mn></mml:math>), necessitating an additional 24-hour infusion to achieve significant reduction after 72 hours (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.004</mml:mn></mml:math>). SAECG data demonstrated a statistically significant decrease after 72 hours (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.04</mml:mn></mml:math>). Apart from two deaths due to advanced heart failure, no major complications were observed. Conclusion . Prolonged infusion of levosimendan without a loading dose is associated with an acceptable clinical and neurohumoral response." @default.
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- W2046334580 date "2011-01-01" @default.
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- W2046334580 title "Efficiency and Safety of Prolonged Levosimendan Infusion in Patients with Acute Heart Failure" @default.
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- W2046334580 doi "https://doi.org/10.4061/2011/342302" @default.
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