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• W2046336522 startingPage "84" @default.
• W2046336522 abstract "Abstract Endotoxins (lipopolysaccharides; LPS) are known to cause multiple organ failure, including myocardial dysfunction. The present study aimed to investigate the mechanism of caffeic acid phenethyl ester (CAPE) protection against LPS‐induced cardiac stress. Rats were allocated into three groups; group 1 served as a normal control group, group 2 (LPS) received a single intraperitoneal injection of LPS (10 mg/kg), group 3 (LPS + CAPE) was injected intraperitoneally with CAPE (10 mg/kg/day; solubilized in saline containing 20% tween 20) throughout a period of 10 days prior to LPS injection. Rats were maintained 4 h before sacrifice. Caffeic acid phenethyl ester pretreatment normalized LPS‐enhanced activities of serum creatine kinase (CK) and lactate dehydrogenase (LDH) as well as glutathione peroxidase (GPx), and myeloperoxidase (MPO) in cardiac tissue. A significant reduction of the elevated levels of serum tumor necrosis factor‐alpha (TNF‐α) as well as serum and cardiac nitrite/nitrate (NO x ) was achieved after CAPE pretreatment. CAPE also restored malondialdelyde (MDA), reduced glutathione (GSH), and cytosolic calcium (Ca 2+ ) levels in the heart. A marked induction of cardiac heme oxygenase‐1 (HO‐1) protein level was detected in CAPE‐pretreated group. Whereas, LPS‐induced reduction of adenosine triphosphate (ATP) and phosphocreatine (PCr) levels was insignificantly changed. Conclusively, the early treatment with CAPE maintained antioxidant defences, reduced oxidative injury, cytokine damage, and inflammation but did not markedly improve energy status in cardiac tissue. The beneficial effect of CAPE might be mediated, at least in part, by the superinduction of HO‐1. © 2010 Wiley Periodicals, Inc. J Biochem Mol Toxicol 25:84–94 2011; View this article online at wileyonlinelibrary.com . DOI 10.1002/jbt.20362" @default.
• W2046336522 created "2016-06-24" @default.
• W2046336522 creator A5017588202 @default.
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• W2046336522 date "2010-12-01" @default.
• W2046336522 modified "2023-10-11" @default.
• W2046336522 title "Effects of caffeic acid phenethyl ester on endotoxin-induced cardiac stress in rats: A possible mechanism of protection" @default.
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• W2046336522 doi "https://doi.org/10.1002/jbt.20362" @default.
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• W2046336522 hasPublicationYear "2010" @default.
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