FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046339785> ?p ?o ?g. }

• W2046339785 endingPage "L768" @default.
• W2046339785 startingPage "L760" @default.
• W2046339785 abstract "Positron emission tomographic imaging after administration of the glucose analog fluorine-18 fluorodeoxyglucose ([18F]FDG) may be useful to study neutrophilic inflammation of the lungs. In this study, we sought to determine the specificity of the increase in lung [18F]FDG uptake after intraperitoneal endotoxin (Etx) for neutrophil influx into mouse lungs and to determine the regulation of glucose uptake after Etx by Toll-like receptors (TLRs) and TNF-alpha. Lung tissue radioactivity measurements by imaging were validated against counts in a gamma well counter. Glucose uptake was quantified as the [18F]FDG tissue-to-blood radioactivity ratio (TBR) after validating this measure against the gold standard measure of glucose uptake, the net influx rate constant. TBR measurements were made in a control group (no intervention), a group administered Etx, and a group administered Etx plus an additional agent (e.g., vinblastine) or Etx administered to a mutant mouse strain. The glucose uptake measurements were compared with measurements of myeloperoxidase. Increases in TBR after Etx were significantly but not completely eliminated by neutrophil depletion with vinblastine. Increases in TBR after Etx were consistent with signaling via either TLR-4 or TLR-2 (the latter probably secondary to peptidoglycan contaminants in Etx preparation) and were decreased by drug inhibition of TLR-4 but not by inhibition of TNF-alpha. Thus molecular imaging can be used to noninvasively monitor biological effects of Etx on lungs in mice, and changes in lung glucose uptake can be used to monitor effects of anti-inflammatory agents. Such imaging capacity provides a powerful new paradigm for translational mouse-to-human pulmonary research." @default.
• W2046339785 created "2016-06-24" @default.
• W2046339785 creator A5000807500 @default.
• W2046339785 creator A5019254570 @default.
• W2046339785 creator A5023007142 @default.
• W2046339785 creator A5025215536 @default.
• W2046339785 creator A5040340330 @default.
• W2046339785 creator A5070307948 @default.
• W2046339785 date "2005-11-01" @default.
• W2046339785 modified "2023-09-24" @default.
• W2046339785 title "Molecular imaging of lung glucose uptake after endotoxin in mice" @default.
• W2046339785 cites W1544615856 @default.
• W2046339785 cites W1970174650 @default.
• W2046339785 cites W1988253866 @default.
• W2046339785 cites W1990709604 @default.
• W2046339785 cites W199132020 @default.
• W2046339785 cites W1994168320 @default.
• W2046339785 cites W2002924981 @default.
• W2046339785 cites W2007940553 @default.
• W2046339785 cites W2008339675 @default.
• W2046339785 cites W2010465546 @default.
• W2046339785 cites W2032314319 @default.
• W2046339785 cites W2037077612 @default.
• W2046339785 cites W2049660721 @default.
• W2046339785 cites W2050192015 @default.
• W2046339785 cites W2050444234 @default.
• W2046339785 cites W2051228374 @default.
• W2046339785 cites W2052514393 @default.
• W2046339785 cites W2057809738 @default.
• W2046339785 cites W2066347075 @default.
• W2046339785 cites W2068053486 @default.
• W2046339785 cites W2083162623 @default.
• W2046339785 cites W2086054576 @default.
• W2046339785 cites W2091352043 @default.
• W2046339785 cites W2092078486 @default.
• W2046339785 cites W2097389043 @default.
• W2046339785 cites W2098504447 @default.
• W2046339785 cites W2110061490 @default.
• W2046339785 cites W2115834096 @default.
• W2046339785 cites W2115893060 @default.
• W2046339785 cites W2119628454 @default.
• W2046339785 cites W2130827011 @default.
• W2046339785 cites W2149611550 @default.
• W2046339785 cites W2149697611 @default.
• W2046339785 cites W2151593963 @default.
• W2046339785 cites W2223493887 @default.
• W2046339785 cites W4231656159 @default.
• W2046339785 cites W4231779627 @default.
• W2046339785 doi "https://doi.org/10.1152/ajplung.00146.2005" @default.
• W2046339785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15980036" @default.
• W2046339785 hasPublicationYear "2005" @default.
• W2046339785 type Work @default.
• W2046339785 sameAs 2046339785 @default.
• W2046339785 citedByCount "47" @default.
• W2046339785 countsByYear W20463397852012 @default.
• W2046339785 countsByYear W20463397852013 @default.
• W2046339785 countsByYear W20463397852014 @default.
• W2046339785 countsByYear W20463397852015 @default.
• W2046339785 countsByYear W20463397852016 @default.
• W2046339785 countsByYear W20463397852017 @default.
• W2046339785 countsByYear W20463397852018 @default.
• W2046339785 countsByYear W20463397852019 @default.
• W2046339785 countsByYear W20463397852021 @default.
• W2046339785 countsByYear W20463397852022 @default.
• W2046339785 crossrefType "journal-article" @default.
• W2046339785 hasAuthorship W2046339785A5000807500 @default.
• W2046339785 hasAuthorship W2046339785A5019254570 @default.
• W2046339785 hasAuthorship W2046339785A5023007142 @default.
• W2046339785 hasAuthorship W2046339785A5025215536 @default.
• W2046339785 hasAuthorship W2046339785A5040340330 @default.
• W2046339785 hasAuthorship W2046339785A5070307948 @default.
• W2046339785 hasConcept C126322002 @default.
• W2046339785 hasConcept C136339569 @default.
• W2046339785 hasConcept C150903083 @default.
• W2046339785 hasConcept C185592680 @default.
• W2046339785 hasConcept C203014093 @default.
• W2046339785 hasConcept C203565725 @default.
• W2046339785 hasConcept C207001950 @default.
• W2046339785 hasConcept C2776914184 @default.
• W2046339785 hasConcept C2777714996 @default.
• W2046339785 hasConcept C2777866211 @default.
• W2046339785 hasConcept C2779306644 @default.
• W2046339785 hasConcept C71924100 @default.
• W2046339785 hasConcept C86803240 @default.
• W2046339785 hasConcept C98274493 @default.
• W2046339785 hasConceptScore W2046339785C126322002 @default.
• W2046339785 hasConceptScore W2046339785C136339569 @default.
• W2046339785 hasConceptScore W2046339785C150903083 @default.
• W2046339785 hasConceptScore W2046339785C185592680 @default.
• W2046339785 hasConceptScore W2046339785C203014093 @default.
• W2046339785 hasConceptScore W2046339785C203565725 @default.
• W2046339785 hasConceptScore W2046339785C207001950 @default.
• W2046339785 hasConceptScore W2046339785C2776914184 @default.
• W2046339785 hasConceptScore W2046339785C2777714996 @default.
• W2046339785 hasConceptScore W2046339785C2777866211 @default.
• W2046339785 hasConceptScore W2046339785C2779306644 @default.
• W2046339785 hasConceptScore W2046339785C71924100 @default.
• W2046339785 hasConceptScore W2046339785C86803240 @default.

• next