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• W2046340532 abstract "Abstract The distribution and excretion of [ 14 C]alcohol-labeled cismethrin and bioresmethrin was determined after intravenous administration to rats. Initially the label distribution of both isomers was similar, but differences occurred at later times mainly due to the retention of 5-benzyl-3-furylcarboxylic acid, a metabolite of bioresmethrin, in high concentration in the blood. Retention of this metabolite accounted for the slower excretion of bioresmethrin label compared to cismethrin. After administration of either isomer, parent pyrethroid was rapidly cleared from the blood and liver, and both isomers rapidly entered the central nervous system reaching peak concentrations within 2–5 min. Brain cismethrin concentrations exceeding 3.5 nmol/g were associated only with animals showing tremors. These levels of cismethrin are maintained for up to 30 min but bioresmethrin was depleted more rapidly possibly due to brain metabolism. It is concluded that the low toxicity of bioresmethrin is possibly due to the inability of this isomer to interact with the site of action in the central nervous system and not, as previously suggested, primarily because of more rapid metabolism in the liver." @default.
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• W2046340532 date "1980-06-01" @default.
• W2046340532 modified "2023-09-23" @default.
• W2046340532 title "The relationship between the pharmacokinetics of intravenous cismethrin and bioresmethrin and their mammalian toxicity" @default.
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• W2046340532 doi "https://doi.org/10.1016/0048-3575(80)90127-3" @default.
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