FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046341493> ?p ?o ?g. }

• W2046341493 abstract "MicroRNAs are involved in phenotypic switching of smooth muscle cells (SMCs). Brg1-containing SWI/SNF chromatin-remodeling complexes also play an important role in controlling the phenotype of SMCs. We thus determined whether Brg1 influences the transcription of microRNAs in SMCs. Microarray and quantitative RT-PCR analysis of smooth muscle from mice harboring smooth muscle-specific deletion of Brg1 revealed altered expression of several microRNAs, including miRs-143/145 and miR-133. Ablation of Brg1 in SMCs in vitro either by expression of dominant negative Brg1 or Brg1 knock-out attenuated miRs-143/145 expression. Knockdown of serum response factor (SRF) in SMCs significantly reduced the expression levels of miRs-143/145 and miR-133, whereas knockdown of myocardin only attenuated miRs-143/145 expression. Myocardin induced expression of miRs-143/145 and miR-133a and increased SRF binding to these genes in 10T1/2 cells. This myocardin-mediated induction was attenuated by dominant negative Brg1. In Brg1-null SW13 cells, miRs-143/145 were dramatically induced by myocardin only in the presence of Brg1, whereas miR-133 was not induced by myocardin in a Brg1-dependent manner. Chromatin immunoprecipitation assays demonstrated that in the presence of Brg1, myocardin increased SRF binding to both the miRs-143/145 and miR-133a loci. Together, these data suggest a mechanism in which Brg1-containing SWI/SNF complexes are required for myocardin to induce expression of miRs-143/145 in smooth muscle cells. In contrast, miR-133 expression appears to be regulated by Brg1-containing chromatin remodeling complexes in a partially SRF-dependent, although largely myocardin-independent manner. SWI/SNF-mediated chromatin remodeling thus regulates the phenotype of smooth muscle by affecting expression of protein-coding genes and microRNAs." @default.
• W2046341493 created "2016-06-24" @default.
• W2046341493 creator A5012096156 @default.
• W2046341493 creator A5024845093 @default.
• W2046341493 date "2013-03-01" @default.
• W2046341493 modified "2023-10-01" @default.
• W2046341493 title "Regulation of MicroRNAs by Brahma-related Gene 1 (Brg1) in Smooth Muscle Cells" @default.
• W2046341493 cites W1636974729 @default.
• W2046341493 cites W1967738006 @default.
• W2046341493 cites W1981283223 @default.
• W2046341493 cites W1986376020 @default.
• W2046341493 cites W1986903527 @default.
• W2046341493 cites W1996630410 @default.
• W2046341493 cites W1997524334 @default.
• W2046341493 cites W2009872881 @default.
• W2046341493 cites W2018621592 @default.
• W2046341493 cites W2020820932 @default.
• W2046341493 cites W2026472364 @default.
• W2046341493 cites W2034640099 @default.
• W2046341493 cites W2046372092 @default.
• W2046341493 cites W2055689986 @default.
• W2046341493 cites W2074974586 @default.
• W2046341493 cites W2080696342 @default.
• W2046341493 cites W2086775412 @default.
• W2046341493 cites W2094940134 @default.
• W2046341493 cites W2097666176 @default.
• W2046341493 cites W2100467655 @default.
• W2046341493 cites W2103136476 @default.
• W2046341493 cites W2120156784 @default.
• W2046341493 cites W2121822802 @default.
• W2046341493 cites W2124239182 @default.
• W2046341493 cites W2126677920 @default.
• W2046341493 cites W2130265677 @default.
• W2046341493 cites W2135022743 @default.
• W2046341493 cites W2156322485 @default.
• W2046341493 cites W2157647985 @default.
• W2046341493 cites W2168331489 @default.
• W2046341493 cites W2171241454 @default.
• W2046341493 cites W2171559697 @default.
• W2046341493 cites W2548599454 @default.
• W2046341493 doi "https://doi.org/10.1074/jbc.m112.409474" @default.
• W2046341493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3585074" @default.
• W2046341493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23339192" @default.
• W2046341493 hasPublicationYear "2013" @default.
• W2046341493 type Work @default.
• W2046341493 sameAs 2046341493 @default.
• W2046341493 citedByCount "16" @default.
• W2046341493 countsByYear W20463414932013 @default.
• W2046341493 countsByYear W20463414932014 @default.
• W2046341493 countsByYear W20463414932015 @default.
• W2046341493 countsByYear W20463414932016 @default.
• W2046341493 countsByYear W20463414932017 @default.
• W2046341493 countsByYear W20463414932018 @default.
• W2046341493 countsByYear W20463414932019 @default.
• W2046341493 countsByYear W20463414932021 @default.
• W2046341493 countsByYear W20463414932023 @default.
• W2046341493 crossrefType "journal-article" @default.
• W2046341493 hasAuthorship W2046341493A5012096156 @default.
• W2046341493 hasAuthorship W2046341493A5024845093 @default.
• W2046341493 hasBestOaLocation W20463414931 @default.
• W2046341493 hasConcept C101762097 @default.
• W2046341493 hasConcept C104317684 @default.
• W2046341493 hasConcept C134320426 @default.
• W2046341493 hasConcept C145059251 @default.
• W2046341493 hasConcept C150194340 @default.
• W2046341493 hasConcept C153911025 @default.
• W2046341493 hasConcept C166941617 @default.
• W2046341493 hasConcept C167227067 @default.
• W2046341493 hasConcept C173396325 @default.
• W2046341493 hasConcept C185592680 @default.
• W2046341493 hasConcept C2780286377 @default.
• W2046341493 hasConcept C54355233 @default.
• W2046341493 hasConcept C69053785 @default.
• W2046341493 hasConcept C83640560 @default.
• W2046341493 hasConcept C86803240 @default.
• W2046341493 hasConcept C95444343 @default.
• W2046341493 hasConceptScore W2046341493C101762097 @default.
• W2046341493 hasConceptScore W2046341493C104317684 @default.
• W2046341493 hasConceptScore W2046341493C134320426 @default.
• W2046341493 hasConceptScore W2046341493C145059251 @default.
• W2046341493 hasConceptScore W2046341493C150194340 @default.
• W2046341493 hasConceptScore W2046341493C153911025 @default.
• W2046341493 hasConceptScore W2046341493C166941617 @default.
• W2046341493 hasConceptScore W2046341493C167227067 @default.
• W2046341493 hasConceptScore W2046341493C173396325 @default.
• W2046341493 hasConceptScore W2046341493C185592680 @default.
• W2046341493 hasConceptScore W2046341493C2780286377 @default.
• W2046341493 hasConceptScore W2046341493C54355233 @default.
• W2046341493 hasConceptScore W2046341493C69053785 @default.
• W2046341493 hasConceptScore W2046341493C83640560 @default.
• W2046341493 hasConceptScore W2046341493C86803240 @default.
• W2046341493 hasConceptScore W2046341493C95444343 @default.
• W2046341493 hasLocation W20463414931 @default.
• W2046341493 hasLocation W20463414932 @default.
• W2046341493 hasLocation W20463414933 @default.
• W2046341493 hasLocation W20463414934 @default.
• W2046341493 hasOpenAccess W2046341493 @default.
• W2046341493 hasPrimaryLocation W20463414931 @default.
• W2046341493 hasRelatedWork W1957217958 @default.
• W2046341493 hasRelatedWork W2009535942 @default.

• next