Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046342372> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2046342372 abstract "The mitochondrial theory of aging suggests that an accumulation of defective mitochondria leads to loss of cell viability. The challenge is to explain how mitochondrial defects accumulate within cells, and why this process is more evident in postmitotic than in dividing cells. We describe a new mathematical model incorporating two critical features: (a) defective mitochondria are turned over more slowly than intact ones, and (b) defective mitochondria suffer a growth disadvantage. We also model the effect of cell division on the accumulation of defective mitochondria. The results support the mitochondrial theory and explain many of the observed data. The relationship of the mitochondrial theory to the suggested role of telomere loss in cell replicative senescence is discussed. We suggest that because of differences in the kinetics of their impact on cells, these two mechanisms have different relative importance for in vivo and in vitro cell aging." @default.
- W2046342372 created "2016-06-24" @default.
- W2046342372 creator A5037656057 @default.
- W2046342372 creator A5042756729 @default.
- W2046342372 date "1999-01-01" @default.
- W2046342372 modified "2023-09-27" @default.
- W2046342372 title "Modeling the Role of Mitochondrial Mutations in Cellular Aging" @default.
- W2046342372 cites W145554909 @default.
- W2046342372 cites W1518489158 @default.
- W2046342372 cites W1590867470 @default.
- W2046342372 cites W1972615369 @default.
- W2046342372 cites W1973042689 @default.
- W2046342372 cites W1974396693 @default.
- W2046342372 cites W1976273464 @default.
- W2046342372 cites W1981327924 @default.
- W2046342372 cites W1982439221 @default.
- W2046342372 cites W1993091967 @default.
- W2046342372 cites W1994496497 @default.
- W2046342372 cites W2004002095 @default.
- W2046342372 cites W2008723540 @default.
- W2046342372 cites W2010094123 @default.
- W2046342372 cites W2015607124 @default.
- W2046342372 cites W2025907197 @default.
- W2046342372 cites W2031619656 @default.
- W2046342372 cites W2039006304 @default.
- W2046342372 cites W2041793728 @default.
- W2046342372 cites W2048339025 @default.
- W2046342372 cites W2050821204 @default.
- W2046342372 cites W2061574765 @default.
- W2046342372 cites W2064502414 @default.
- W2046342372 cites W2071673220 @default.
- W2046342372 cites W2071869532 @default.
- W2046342372 cites W2086896876 @default.
- W2046342372 cites W2108482850 @default.
- W2046342372 cites W2126737200 @default.
- W2046342372 cites W2134857136 @default.
- W2046342372 cites W2500572885 @default.
- W2046342372 doi "https://doi.org/10.1089/rej.1.1999.2.243" @default.
- W2046342372 hasPublicationYear "1999" @default.
- W2046342372 type Work @default.
- W2046342372 sameAs 2046342372 @default.
- W2046342372 citedByCount "3" @default.
- W2046342372 countsByYear W20463423722012 @default.
- W2046342372 crossrefType "journal-article" @default.
- W2046342372 hasAuthorship W2046342372A5037656057 @default.
- W2046342372 hasAuthorship W2046342372A5042756729 @default.
- W2046342372 hasConcept C104317684 @default.
- W2046342372 hasConcept C1491633281 @default.
- W2046342372 hasConcept C177336024 @default.
- W2046342372 hasConcept C202751555 @default.
- W2046342372 hasConcept C24586158 @default.
- W2046342372 hasConcept C28859421 @default.
- W2046342372 hasConcept C522857546 @default.
- W2046342372 hasConcept C54355233 @default.
- W2046342372 hasConcept C552990157 @default.
- W2046342372 hasConcept C85813293 @default.
- W2046342372 hasConcept C86803240 @default.
- W2046342372 hasConcept C95444343 @default.
- W2046342372 hasConceptScore W2046342372C104317684 @default.
- W2046342372 hasConceptScore W2046342372C1491633281 @default.
- W2046342372 hasConceptScore W2046342372C177336024 @default.
- W2046342372 hasConceptScore W2046342372C202751555 @default.
- W2046342372 hasConceptScore W2046342372C24586158 @default.
- W2046342372 hasConceptScore W2046342372C28859421 @default.
- W2046342372 hasConceptScore W2046342372C522857546 @default.
- W2046342372 hasConceptScore W2046342372C54355233 @default.
- W2046342372 hasConceptScore W2046342372C552990157 @default.
- W2046342372 hasConceptScore W2046342372C85813293 @default.
- W2046342372 hasConceptScore W2046342372C86803240 @default.
- W2046342372 hasConceptScore W2046342372C95444343 @default.
- W2046342372 hasLocation W20463423721 @default.
- W2046342372 hasOpenAccess W2046342372 @default.
- W2046342372 hasPrimaryLocation W20463423721 @default.
- W2046342372 hasRelatedWork W1514509974 @default.
- W2046342372 hasRelatedWork W1926098131 @default.
- W2046342372 hasRelatedWork W1970800028 @default.
- W2046342372 hasRelatedWork W1983594275 @default.
- W2046342372 hasRelatedWork W1984630129 @default.
- W2046342372 hasRelatedWork W1992712867 @default.
- W2046342372 hasRelatedWork W2042367738 @default.
- W2046342372 hasRelatedWork W2044624385 @default.
- W2046342372 hasRelatedWork W2057495460 @default.
- W2046342372 hasRelatedWork W2073693479 @default.
- W2046342372 hasRelatedWork W2090665599 @default.
- W2046342372 hasRelatedWork W2360500113 @default.
- W2046342372 hasRelatedWork W2528045227 @default.
- W2046342372 hasRelatedWork W2560157086 @default.
- W2046342372 hasRelatedWork W2565159558 @default.
- W2046342372 hasRelatedWork W2783356125 @default.
- W2046342372 hasRelatedWork W2904591703 @default.
- W2046342372 hasRelatedWork W2941744713 @default.
- W2046342372 hasRelatedWork W2999736313 @default.
- W2046342372 hasRelatedWork W51555640 @default.
- W2046342372 isParatext "false" @default.
- W2046342372 isRetracted "false" @default.
- W2046342372 magId "2046342372" @default.
- W2046342372 workType "article" @default.