FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046348093> ?p ?o ?g. }

• W2046348093 endingPage "990" @default.
• W2046348093 startingPage "980" @default.
• W2046348093 abstract "Lung contusion (LC) is a unique direct and focal insult that is considered a major risk factor for the initiation of acute lung injury and acute respiratory distress syndrome. We have shown recently that consumption of nitric oxide (due to excess superoxide) resulting in peroxynitrite formation leads to decreased vascular reactivity after LC. In this study, we set out to determine whether the superoxide scavenger Mn (III) tetrakis (4-benzoic acid) porphyrin chloride (MnTBAP) plays a protective role in alleviating acute inflammatory response and injury in LC.Nonlethal, closed-chest, bilateral LC was induced in a rodent model. Administration of the superoxide dismutase mimetic MnTBAP concurrently in LC in rats was performed, and bronchoalveolar lavage (BAL) and lung samples were analyzed for degree of injury and inflammation at 5 and 24 h after the insult. The extent of injury was assessed by the measurement of cells and albumin with cytokine levels in the BAL and lungs. Lung samples were subjected to H&E and superoxide staining with dihydro-ethidium. Protein-bound dityrosine and nitrotyrosine levels were quantified in lung tissue by tandem mass spectrometry.The degrees of lung injury after LC as determined by BAL albumin levels were significantly decreased in the MnTBAP-administered rats at all the time points when compared to the corresponding controls. The release of proinflammatory cytokines and BAL neutrophils was significantly less in the rats administered MnTBAP after LC. Administration of MnTBAP decreased tissue damage and decreased necrosis and neutrophil-rich exudate at the 24-h time point. Staining for superoxide anions showed significantly greater intensity in the lung samples from the LC group compared to the LC+ MnTBAP group. High-performance liquid chromatography/tandem mass spectrometry revealed that MnTBAP treatment significantly attenuated dityrosine and nitrotyrosine levels, consistent with decreased oxidant injury.Superoxide dismutase mimetic-MnTBAP reduced permeability and oxidative injury in LC and may have a therapeutic role in diminishing inflammation in LC." @default.
• W2046348093 created "2016-06-24" @default.
• W2046348093 creator A5003732931 @default.
• W2046348093 creator A5009240466 @default.
• W2046348093 creator A5013036617 @default.
• W2046348093 creator A5018728349 @default.
• W2046348093 creator A5029984902 @default.
• W2046348093 creator A5044926801 @default.
• W2046348093 creator A5059865743 @default.
• W2046348093 creator A5083540704 @default.
• W2046348093 creator A5088661513 @default.
• W2046348093 date "2013-11-01" @default.
• W2046348093 modified "2023-10-18" @default.
• W2046348093 title "The protective role of MnTBAP in oxidant-mediated injury and inflammation in a rat model of lung contusion" @default.
• W2046348093 cites W1484356492 @default.
• W2046348093 cites W1533259206 @default.
• W2046348093 cites W1978181112 @default.
• W2046348093 cites W1984443887 @default.
• W2046348093 cites W2002173659 @default.
• W2046348093 cites W2002982667 @default.
• W2046348093 cites W2015772920 @default.
• W2046348093 cites W2019140768 @default.
• W2046348093 cites W2026551182 @default.
• W2046348093 cites W2027498284 @default.
• W2046348093 cites W2028460644 @default.
• W2046348093 cites W2029058958 @default.
• W2046348093 cites W2048492561 @default.
• W2046348093 cites W2052528762 @default.
• W2046348093 cites W2058821788 @default.
• W2046348093 cites W2068572134 @default.
• W2046348093 cites W2073349285 @default.
• W2046348093 cites W2074198144 @default.
• W2046348093 cites W2074880086 @default.
• W2046348093 cites W2084255431 @default.
• W2046348093 cites W2089747387 @default.
• W2046348093 cites W2094655287 @default.
• W2046348093 cites W2099556955 @default.
• W2046348093 cites W2105017863 @default.
• W2046348093 cites W2123169923 @default.
• W2046348093 cites W2137261693 @default.
• W2046348093 cites W2148685973 @default.
• W2046348093 cites W2168042509 @default.
• W2046348093 cites W2168156495 @default.
• W2046348093 cites W4211136402 @default.
• W2046348093 cites W4242516469 @default.
• W2046348093 cites W4252911190 @default.
• W2046348093 cites W92044824 @default.
• W2046348093 doi "https://doi.org/10.1016/j.surg.2013.05.023" @default.
• W2046348093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3855248" @default.
• W2046348093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24139490" @default.
• W2046348093 hasPublicationYear "2013" @default.
• W2046348093 type Work @default.
• W2046348093 sameAs 2046348093 @default.
• W2046348093 citedByCount "23" @default.
• W2046348093 countsByYear W20463480932014 @default.
• W2046348093 countsByYear W20463480932015 @default.
• W2046348093 countsByYear W20463480932016 @default.
• W2046348093 countsByYear W20463480932017 @default.
• W2046348093 countsByYear W20463480932019 @default.
• W2046348093 countsByYear W20463480932020 @default.
• W2046348093 countsByYear W20463480932021 @default.
• W2046348093 countsByYear W20463480932022 @default.
• W2046348093 crossrefType "journal-article" @default.
• W2046348093 hasAuthorship W2046348093A5003732931 @default.
• W2046348093 hasAuthorship W2046348093A5009240466 @default.
• W2046348093 hasAuthorship W2046348093A5013036617 @default.
• W2046348093 hasAuthorship W2046348093A5018728349 @default.
• W2046348093 hasAuthorship W2046348093A5029984902 @default.
• W2046348093 hasAuthorship W2046348093A5044926801 @default.
• W2046348093 hasAuthorship W2046348093A5059865743 @default.
• W2046348093 hasAuthorship W2046348093A5083540704 @default.
• W2046348093 hasAuthorship W2046348093A5088661513 @default.
• W2046348093 hasBestOaLocation W20463480932 @default.
• W2046348093 hasConcept C126322002 @default.
• W2046348093 hasConcept C142724271 @default.
• W2046348093 hasConcept C164027704 @default.
• W2046348093 hasConcept C181199279 @default.
• W2046348093 hasConcept C185592680 @default.
• W2046348093 hasConcept C203014093 @default.
• W2046348093 hasConcept C2775838275 @default.
• W2046348093 hasConcept C2776151105 @default.
• W2046348093 hasConcept C2776914184 @default.
• W2046348093 hasConcept C2777622882 @default.
• W2046348093 hasConcept C2777714996 @default.
• W2046348093 hasConcept C2777961210 @default.
• W2046348093 hasConcept C2778784160 @default.
• W2046348093 hasConcept C2779385521 @default.
• W2046348093 hasConcept C2780795997 @default.
• W2046348093 hasConcept C519581460 @default.
• W2046348093 hasConcept C55493867 @default.
• W2046348093 hasConcept C71924100 @default.
• W2046348093 hasConcept C98274493 @default.
• W2046348093 hasConceptScore W2046348093C126322002 @default.
• W2046348093 hasConceptScore W2046348093C142724271 @default.
• W2046348093 hasConceptScore W2046348093C164027704 @default.
• W2046348093 hasConceptScore W2046348093C181199279 @default.
• W2046348093 hasConceptScore W2046348093C185592680 @default.
• W2046348093 hasConceptScore W2046348093C203014093 @default.

• next