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- W2046348186 abstract "The direct inhibitory effect of gonadotropin-releasing hormone (GnRH) upon testicular androgen production was studied in cultured testicular cells. Enzyme-dispersed testicular cells from immature hypophysectomized rats were cultured for 6 days in a serum-free medium with or without various hormones. Culture media were changed every 2 days and media concentration of androgens was measured by radioimmunoassay. The testis cultures from immature rats secrete predominately 5α-androstane-3α,17β-diol (A-diol) and androsterone but negligible amounts of androstenedione, testosterone and dihydrotestosterone. Incubation of testicular cells with hCG and FSH increased A-diol and androsterone production as compared to control cultures. In contrast, treatment with GnRH or a GnRH agonist (des-Gly 10 ,D-Leu 6 (N α Me)Leu 7 , Pro 9 NHEt-GnRH) inhibited the gonadotropin effect in a dose-dependent manner; 10 −8 M GnRH inhibited A-diol production by 2̃0% on day 4 and 6 of culture whereas 10 −6 M GnRH inhibited A-diol production by > 80%. The observed effect of GnRH upon testicular cells in primary culture demonstrates that the hypothalamic peptide directly inhibits testicular steroidogenesis." @default.
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- W2046348186 title "Inhibitory effect of gonadotropin releasing hormone upon cultured testicular cells" @default.
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- W2046348186 doi "https://doi.org/10.1016/0303-7207(81)90029-0" @default.
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