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• W2046348530 abstract "Mammary gland anlagen from the 17-day fetal rat were grown for six and nine days in organ culture in basal (Waymouth's agar) nutrient medium only and with added insulin, insulin and prolactin, or insulin, prolactin, and aldosterone. Prior work has shown that the three-hormone combination is most effective in stimulating histologic differentiation and the synthesis of a casein-like material. Cultured explants from each group were examined by electron microscopy and compared with 17-day anlagen before culture and with the mammary gland of the newborn female rat. The 17-day anlage is a solid mass of cells, surrounded by a basal lamina and a partially oriented sheath of mesenchyme cells; ultrastructure of the epithelial cells shows the characteristics of fetal tissue. At birth, the normal mammary gland consists of an extensively branching system of ductules with continuous lumina and a well developed sheath of connective tissue. Luminal surfaces of epithelial cells bear numerous microvilli and are ringed by continuous belts of tight junctions. Fat droplets are present in cells and lumina and the Golgi apparatus is abundant but not visibly active in protein secretion; rough endoplasmic reticulum is present in moderate quantity and occasionally is distended with low-density, homogeneous content. Organ culture without hormones resulted in epithelial cell proliferation; however, the basal lamina disappeared, no connective-tissue sheath developed, and the epithelial mass showed no organized growth pattern. Some small, true lumina appeared within the cell mass. With insulin added, the anlagen ramified moderately and formed true lumina that were distinct but often discontinuous; the enveloping connective and adipose tissues were well developed. Epithelial cells showed little organellar differentiation but contained many fat droplets and abundant glycogen. In the presence of insulin and prolactin, ductal organization was much improved, whereas organellar differentiation within epithelial cells was only slightly better than with insulin alone. With the three-hormone combination, histologic organization and ultrastructural differentiation attained levels similar to those in the gland of the newborn rat; in addition, the Golgi complex in some cells was conspicuously active and many Golgi vesicles contained condensed material similar to the protein secretion products seen in pregnant and lactating mammary glands." @default.
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• W2046348530 date "1970-05-01" @default.
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• W2046348530 title "Ultrastructure of rat mammary-gland anlagenin vivo and after culture with hormones" @default.
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• W2046348530 doi "https://doi.org/10.1002/jez.1401740109" @default.
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