FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046349754> ?p ?o ?g. }

• W2046349754 endingPage "73" @default.
• W2046349754 startingPage "66" @default.
• W2046349754 abstract "Post-ischemic inflammation plays an important role in the evolution of brain injury, recovery and repair after stroke. Housing rodents in an enriched environment provides multisensory stimulation to the brain and enhances functional recovery after experimental stroke, also depressing the release of cytokines and chemokines in the peri-infarct. In order to identify targets for late stroke treatment, we studied the dynamics of inflammation and the contribution of resident Toll-like receptor 2 (TLR2) expressing microglia cells. We took advantage of the biophotonic/bioluminescent imaging technique using the reporter mouse-expressing luciferase and GFP reporter genes under transcriptional control of the murine TLR2 promoter (TLR2-luc/GFP mice) for non-invasive in vivo analysis of TLR2 activation/response in photothrombotic stroke after differential housing. Real-time imaging at 1 day after stroke, revealed up-regulation of TLR2 in response to photothrombotic stroke that subsequently declined over time of recovery (14 days). The inflammatory response was persistently down-regulated within days of enriched housing, enhancing recovery of lost sensori-motor function in TLR2-luc mice without affecting infarct size. The number of YM1-expressing microglia in the peri-infarct and areas remote from the infarct was also markedly attenuated. Using a live imaging approach, we demonstrate that multisensory stimulation rapidly, persistently and generally attenuates brain inflammation after experimental stroke, reducing the TLR2 response and leading to improved neurological outcome. TLR2-expressing microglia cells may provide targets for new stroke therapeutics." @default.
• W2046349754 created "2016-06-24" @default.
• W2046349754 creator A5020540455 @default.
• W2046349754 creator A5047812841 @default.
• W2046349754 creator A5053165689 @default.
• W2046349754 creator A5071331742 @default.
• W2046349754 creator A5077386117 @default.
• W2046349754 date "2014-06-01" @default.
• W2046349754 modified "2023-10-16" @default.
• W2046349754 title "Enriched housing down-regulates the Toll-like receptor 2 response in the mouse brain after experimental stroke" @default.
• W2046349754 cites W1483162601 @default.
• W2046349754 cites W1774728488 @default.
• W2046349754 cites W1834139870 @default.
• W2046349754 cites W1915121024 @default.
• W2046349754 cites W1931754955 @default.
• W2046349754 cites W1967114933 @default.
• W2046349754 cites W1969832079 @default.
• W2046349754 cites W1976010325 @default.
• W2046349754 cites W1976589901 @default.
• W2046349754 cites W1979096652 @default.
• W2046349754 cites W1983368104 @default.
• W2046349754 cites W1988086690 @default.
• W2046349754 cites W1992751386 @default.
• W2046349754 cites W1993529966 @default.
• W2046349754 cites W1997751862 @default.
• W2046349754 cites W1999064607 @default.
• W2046349754 cites W2004465286 @default.
• W2046349754 cites W2004524797 @default.
• W2046349754 cites W2004622194 @default.
• W2046349754 cites W2011394277 @default.
• W2046349754 cites W2021715667 @default.
• W2046349754 cites W2023809419 @default.
• W2046349754 cites W2025461456 @default.
• W2046349754 cites W2026255271 @default.
• W2046349754 cites W2026983332 @default.
• W2046349754 cites W2029984783 @default.
• W2046349754 cites W2034052927 @default.
• W2046349754 cites W2043441080 @default.
• W2046349754 cites W2044671618 @default.
• W2046349754 cites W2048380010 @default.
• W2046349754 cites W2049201207 @default.
• W2046349754 cites W2054282296 @default.
• W2046349754 cites W2055679077 @default.
• W2046349754 cites W2056889971 @default.
• W2046349754 cites W2062808637 @default.
• W2046349754 cites W2067946746 @default.
• W2046349754 cites W2080271028 @default.
• W2046349754 cites W2085422191 @default.
• W2046349754 cites W2096192426 @default.
• W2046349754 cites W2112476462 @default.
• W2046349754 cites W2118110686 @default.
• W2046349754 cites W2119573232 @default.
• W2046349754 cites W2134934993 @default.
• W2046349754 cites W2152431890 @default.
• W2046349754 cites W2153891187 @default.
• W2046349754 cites W2154494913 @default.
• W2046349754 cites W2154702871 @default.
• W2046349754 doi "https://doi.org/10.1016/j.nbd.2014.02.010" @default.
• W2046349754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24613658" @default.
• W2046349754 hasPublicationYear "2014" @default.
• W2046349754 type Work @default.
• W2046349754 sameAs 2046349754 @default.
• W2046349754 citedByCount "29" @default.
• W2046349754 countsByYear W20463497542014 @default.
• W2046349754 countsByYear W20463497542015 @default.
• W2046349754 countsByYear W20463497542016 @default.
• W2046349754 countsByYear W20463497542017 @default.
• W2046349754 countsByYear W20463497542018 @default.
• W2046349754 countsByYear W20463497542019 @default.
• W2046349754 countsByYear W20463497542020 @default.
• W2046349754 countsByYear W20463497542021 @default.
• W2046349754 countsByYear W20463497542022 @default.
• W2046349754 countsByYear W20463497542023 @default.
• W2046349754 crossrefType "journal-article" @default.
• W2046349754 hasAuthorship W2046349754A5020540455 @default.
• W2046349754 hasAuthorship W2046349754A5047812841 @default.
• W2046349754 hasAuthorship W2046349754A5053165689 @default.
• W2046349754 hasAuthorship W2046349754A5071331742 @default.
• W2046349754 hasAuthorship W2046349754A5077386117 @default.
• W2046349754 hasConcept C126322002 @default.
• W2046349754 hasConcept C127413603 @default.
• W2046349754 hasConcept C13373296 @default.
• W2046349754 hasConcept C169760540 @default.
• W2046349754 hasConcept C170493617 @default.
• W2046349754 hasConcept C203014093 @default.
• W2046349754 hasConcept C24998067 @default.
• W2046349754 hasConcept C2776070231 @default.
• W2046349754 hasConcept C2776914184 @default.
• W2046349754 hasConcept C2779830541 @default.
• W2046349754 hasConcept C2780645631 @default.
• W2046349754 hasConcept C2781236682 @default.
• W2046349754 hasConcept C71924100 @default.
• W2046349754 hasConcept C78519656 @default.
• W2046349754 hasConcept C86803240 @default.
• W2046349754 hasConcept C95444343 @default.
• W2046349754 hasConceptScore W2046349754C126322002 @default.
• W2046349754 hasConceptScore W2046349754C127413603 @default.
• W2046349754 hasConceptScore W2046349754C13373296 @default.

• next