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- W2046351635 abstract "Four experiments investigated the effects of amphetamine on retrieval of a “forgotten” maze task. Rats were trained to run a six-unit spatial discrimination maze for food reward. After a 3-week training to test interval, control animals showed significant forgetting as measured by errors, run time, and retracings. Treatments with amphetamine 20 min before the retention test alleviated this forgetting, in that treated animals had a performance which was not different from the last training trial. The effect was dose dependent, effective doses being 0.25 and 0.50 mg/kg; larger doses were ineffective. There was no state-dependent retrieval effect; animals which showed facilitation under amphetamine treatment, continued to perform well when retested without the drug, 24 hr later. A final experiment showed that there was no effect on acquisition, whether the treatment was given before the first, second, or third acquisition trial. The results are discussed in terms of the possible role of catecholamines, central or peripheral, in memory retrieval processes." @default.
- W2046351635 created "2016-06-24" @default.
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- W2046351635 date "1982-10-01" @default.
- W2046351635 modified "2023-09-24" @default.
- W2046351635 title "Memory retrieval enhanced by amphetamine after a long retention interval" @default.
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- W2046351635 doi "https://doi.org/10.1016/s0163-1047(82)90145-5" @default.
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