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- W2046358051 endingPage "1517" @default.
- W2046358051 startingPage "1517" @default.
- W2046358051 abstract "Helicobacter pylori is a highly successful bacterium with a high global prevalence and the infection carries significant disease burden. It is also becoming increasingly difficult to eradicate and the main reason for this is growing primary antibiotic resistance rates in a world where antibiotics are frequently prescribed and readily available. Despite knowing much more about the bacterium since its discovery, such as its genomic makeup and pathogenesis, we have seen declining treatment success. Therefore, clinicians today must be prepared to face one, two or even multiple treatment failures, and should be equipped with sufficient knowledge to decide on the appropriate salvage therapy when this happens. This article discusses the factors contributing to treatment failure and reviews the second and third-line treatment strategies that have been investigated. Established empiric second line treatment options include both bismuth based quadruple therapy and levofloxacin based triple therapy. Antibiotic testing is recommended prior to initiating third line treatment. In the event that antibiotic susceptibility testing is unavailable, third line treatment options include rifabutin, rifaximin and sitafloxacin based therapies." @default.
- W2046358051 created "2016-06-24" @default.
- W2046358051 creator A5022313037 @default.
- W2046358051 creator A5044353130 @default.
- W2046358051 date "2014-01-01" @default.
- W2046358051 modified "2023-10-02" @default.
- W2046358051 title "Second and third line treatment options for<i>Helicobacter pylori</i>eradication" @default.
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- W2046358051 doi "https://doi.org/10.3748/wjg.v20.i6.1517" @default.
- W2046358051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3925860" @default.
- W2046358051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24587627" @default.
- W2046358051 hasPublicationYear "2014" @default.