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• W2046359807 abstract "The reticularis and fasciculata zones of the adrenal cortex are the predominant sources of dehydroepiandrosterone (DHEA) and DHEA-sulphate and contribute directly or indirectly 60-75% of androstenedione and testosterone in women. The specific control of adrenal androgens remains unclear. While ACTH stimulates adrenal androgen secretion, the dissociation of cortisol and androgens occurring during adrenarche and under pathological conditions suggests other factors are involved. Recent studies using human adrenal cells in vitro have demonstrated that the ratio of androgen to cortisol produced is substantially independent of the age and gender of the adrenal, indicating that extra-adrenal factors are of greater importance. beta-Endorphin and joining peptide have been shown to stimulate androgen production in human adrenal cells and to influence ACTH-stimulated steroidogenesis in a manner that promotes adrenal androgen production. The activity of these pro-opiomelanocortin-derived peptides may explain the physiological and pathological dissociations of androgens and cortisol." @default.
• W2046359807 created "2016-06-24" @default.
• W2046359807 creator A5002512027 @default.
• W2046359807 creator A5011749195 @default.
• W2046359807 creator A5072191033 @default.
• W2046359807 creator A5076878027 @default.
• W2046359807 date "1997-06-01" @default.
• W2046359807 modified "2023-09-23" @default.
• W2046359807 title "2 A critical review of the origin and control of adrenal androgens" @default.
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• W2046359807 doi "https://doi.org/10.1016/s0950-3552(97)80035-1" @default.
• W2046359807 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9536209" @default.
• W2046359807 hasPublicationYear "1997" @default.
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