Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046361427> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2046361427 endingPage "43" @default.
- W2046361427 startingPage "31" @default.
- W2046361427 abstract "1. The hepatic microsomal metabolism of N-phenyl-2-naphthylamine (P2NA), an industrial antioxidant and suspected carcinogen, was studied in seven mammalian species to determine if N-dephenylation, reported to occur in vivo, could be demonstrated in vitro and if macromolecular binding occurs without an obligatory N-dephenylation. 2. The rate of hepatic microsomal metabolism decreased in the order: hamster much greater than mouse greater than rat congruent to monkey congruent to dog greater than human congruent to pig. Metabolism was increased by pretreatment with 3-methycholanthrene or phenobarbital and decreased by carbon monoxide or 2-[2,4-dichloro-6-phenyl)phenoxy]-ethylamine, which indicated the involvement of cytochrome P-450 rather than the flavoprotein mixed-function oxidase. 3. All seven species produced two major metabolites identified as 6-hydroxy-P2NA and 4-'hydroxy-P2NA. The carcinogen 2-naphthylamine was not detected in the microsomal incubations. 4. Incubations in the presence of 18O2 indicated that the oxygen incorporated in the products came from molecular oxygen. 5. There was a time-dependent linear increase in covalent binding of P2NA to microsomal protein and the extent of binding approximately paralleled the rate of metabolism. Thus, macromolecular binding of this aromatic amine appears to occur without an obligatory N-dephenylation and may be due to the metabolic formation of epoxides." @default.
- W2046361427 created "2016-06-24" @default.
- W2046361427 creator A5040662730 @default.
- W2046361427 creator A5046441978 @default.
- W2046361427 creator A5085128218 @default.
- W2046361427 date "1982-01-01" @default.
- W2046361427 modified "2023-09-27" @default.
- W2046361427 title "Hepatic microsomal metabolism and macromolecular binding of the antioxidant, n-phenyl-2-naphthylamine" @default.
- W2046361427 cites W1506043065 @default.
- W2046361427 cites W1613401727 @default.
- W2046361427 cites W1775749144 @default.
- W2046361427 cites W2016586155 @default.
- W2046361427 cites W2026802456 @default.
- W2046361427 cites W2037913452 @default.
- W2046361427 cites W2052050945 @default.
- W2046361427 cites W2087835142 @default.
- W2046361427 cites W2125292738 @default.
- W2046361427 cites W2142439989 @default.
- W2046361427 cites W3021828433 @default.
- W2046361427 cites W4236428759 @default.
- W2046361427 cites W4253185740 @default.
- W2046361427 cites W2073932017 @default.
- W2046361427 doi "https://doi.org/10.3109/00498258209052452" @default.
- W2046361427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7090417" @default.
- W2046361427 hasPublicationYear "1982" @default.
- W2046361427 type Work @default.
- W2046361427 sameAs 2046361427 @default.
- W2046361427 citedByCount "13" @default.
- W2046361427 countsByYear W20463614272013 @default.
- W2046361427 countsByYear W20463614272019 @default.
- W2046361427 crossrefType "journal-article" @default.
- W2046361427 hasAuthorship W2046361427A5040662730 @default.
- W2046361427 hasAuthorship W2046361427A5046441978 @default.
- W2046361427 hasAuthorship W2046361427A5085128218 @default.
- W2046361427 hasConcept C114246631 @default.
- W2046361427 hasConcept C134018914 @default.
- W2046361427 hasConcept C181199279 @default.
- W2046361427 hasConcept C185592680 @default.
- W2046361427 hasConcept C2776524530 @default.
- W2046361427 hasConcept C2778575167 @default.
- W2046361427 hasConcept C2780768313 @default.
- W2046361427 hasConcept C38485361 @default.
- W2046361427 hasConcept C526171541 @default.
- W2046361427 hasConcept C55493867 @default.
- W2046361427 hasConcept C62231903 @default.
- W2046361427 hasConcept C86803240 @default.
- W2046361427 hasConcept C87644729 @default.
- W2046361427 hasConceptScore W2046361427C114246631 @default.
- W2046361427 hasConceptScore W2046361427C134018914 @default.
- W2046361427 hasConceptScore W2046361427C181199279 @default.
- W2046361427 hasConceptScore W2046361427C185592680 @default.
- W2046361427 hasConceptScore W2046361427C2776524530 @default.
- W2046361427 hasConceptScore W2046361427C2778575167 @default.
- W2046361427 hasConceptScore W2046361427C2780768313 @default.
- W2046361427 hasConceptScore W2046361427C38485361 @default.
- W2046361427 hasConceptScore W2046361427C526171541 @default.
- W2046361427 hasConceptScore W2046361427C55493867 @default.
- W2046361427 hasConceptScore W2046361427C62231903 @default.
- W2046361427 hasConceptScore W2046361427C86803240 @default.
- W2046361427 hasConceptScore W2046361427C87644729 @default.
- W2046361427 hasIssue "1" @default.
- W2046361427 hasLocation W20463614271 @default.
- W2046361427 hasLocation W20463614272 @default.
- W2046361427 hasOpenAccess W2046361427 @default.
- W2046361427 hasPrimaryLocation W20463614271 @default.
- W2046361427 hasRelatedWork W153049904 @default.
- W2046361427 hasRelatedWork W1969729248 @default.
- W2046361427 hasRelatedWork W2046361427 @default.
- W2046361427 hasRelatedWork W2047704582 @default.
- W2046361427 hasRelatedWork W2056093467 @default.
- W2046361427 hasRelatedWork W2065356065 @default.
- W2046361427 hasRelatedWork W2068257407 @default.
- W2046361427 hasRelatedWork W2074076166 @default.
- W2046361427 hasRelatedWork W66485546 @default.
- W2046361427 hasRelatedWork W2070953544 @default.
- W2046361427 hasVolume "12" @default.
- W2046361427 isParatext "false" @default.
- W2046361427 isRetracted "false" @default.
- W2046361427 magId "2046361427" @default.
- W2046361427 workType "article" @default.