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• W2046364145 abstract "The effects of fasting on the rate of fatty acid synthesis, the properties of the mitochondrial citrate transporter and on pyruvate dehydrogenase activity were investigated in host liver preparations and in “poorly differentiated” Morris hepatoma. The Km for the hepatic mitochondrial citrate transporter of fed rats was 240 μm. This Km increased approximately 2-fold in mitochondria isolated from livers of fasted or diabetic rats. The long-chain fatty acyl CoA content was also approximately 2-fold higher in these mitochondria. In liver mitochondria from fed rats, the Km of the citrate transporter and the long-chain fatty acyl CoA content were both increased significantly only when both l-palmitoyl carnitine and CoASH were added and decreased in parallel when “defatted albumin” was added. When l-palmitoyl carnitine was being oxidized, the Km for the citrate transporter increased. This increase was prevented by the addition of the inhibitor d-palmitoyl carnitine with no significant change in the long-chain fatty acyl CoA content. Similarly this Km could be increased by octanoate only if fatty acid oxidation had occurred in coupled mitochondria, thus implicating fatty acid oxidation as well as the content of fatty acyl CoA in the regulation of this step. The properties of the citrate transporter from hepatoma mitochondria were similar to those of host liver mitochondria, with the exception that in hepatoma mitochondria the Km for the citrate transporter was less than 75 μm. The acid-insoluble CoA content was 180 ± 20 pmoles/mg protein in the hepatoma and remained essentially unchanged in the fasted state, while the acid-insoluble CoA levels in livers from fed rats was 720 ± 80 pmoles/mg protein and were increased to 1050 ± 50 pmoles/mg protein during fasting. After a 36-hr fast, the rate of lipogenesis and the percentage of pyruvate dehydrogenase present in the active form were each decreased by approximately 80% in host liver preparations. In contrast, the rate of lipogenesis by hepatoma slices did not decrease during fasting, and essentially all pyruvate dehydrogenase present was in the active form in hepatomas obtained from either fed or fasted animals. Implications concerning the identification of possible regulatory sites in the control of lipogenesis were discussed in relation to the above observations." @default.
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• W2046364145 date "1975-01-01" @default.
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• W2046364145 title "Role of the citrate transporter in the control of fatty acid synthesis" @default.
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• W2046364145 doi "https://doi.org/10.1016/0065-2571(75)90029-1" @default.
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