FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046369009> ?p ?o ?g. }

• W2046369009 endingPage "6901" @default.
• W2046369009 startingPage "6896" @default.
• W2046369009 abstract "The role of various adhesion molecules in lymphocyte homing to the brain and in inflammatory autoimmune disease of the central nervous system (CNS) was examined in mice. Activated T cell lines and clones expressed CD44 and integrin alpha4, but not L-selectin, and entered the CNS independent of their antigen specificity. mAbs directed against CD44 and integrin alpha4 prevented the transfer of experimental autoimmune encephalomyelitis (EAE) by myelin basic protein-specific T cells. T cells preincubated with anti-CD44 or antiintegrin alpha4 were blocked only partially from entering the brain parenchyma. However, both antibodies efficiently prevented CNS inflammation and clinical expression of EAE when injected in vivo. This effect lasted as long as antibodies were administered. Antibodies specific for L-selectin had no effect on homing of encephalitogenic T cells to the brain or development of EAE. Antiintegrin alpha4 and anti-CD44 did not impair the activation and function of encephalitogenic T cells in vitro and did not deplete integrin alpha4- or CD44-positive cells in vivo. These data suggest that, in the absence of leukocyte recruitment, the entry of a reduced number of activated myelin basic protein-reactive T cells in the CNS is not sufficient for the development and expression of EAE. We propose that antibodies to integrin alpha4 and CD44 prevent clinical disease by partially targeting the primary influx of encephalitogenic T cells and by preventing the secondary influx of leukocytes to lesions initiated by the transferred T cells." @default.
• W2046369009 created "2016-06-24" @default.
• W2046369009 creator A5018804066 @default.
• W2046369009 creator A5030571367 @default.
• W2046369009 creator A5066671501 @default.
• W2046369009 creator A5070044806 @default.
• W2046369009 creator A5082894731 @default.
• W2046369009 date "1999-06-08" @default.
• W2046369009 modified "2023-10-14" @default.
• W2046369009 title "Antibodies to CD44 and integrin α₄, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment" @default.
• W2046369009 cites W1503421252 @default.
• W2046369009 cites W1514064771 @default.
• W2046369009 cites W154283076 @default.
• W2046369009 cites W1545014290 @default.
• W2046369009 cites W1553624503 @default.
• W2046369009 cites W1577146075 @default.
• W2046369009 cites W1660384334 @default.
• W2046369009 cites W1820868233 @default.
• W2046369009 cites W1844950497 @default.
• W2046369009 cites W1909484207 @default.
• W2046369009 cites W1966286149 @default.
• W2046369009 cites W1966684157 @default.
• W2046369009 cites W1969250152 @default.
• W2046369009 cites W1971449558 @default.
• W2046369009 cites W1972325525 @default.
• W2046369009 cites W1974210099 @default.
• W2046369009 cites W1980982223 @default.
• W2046369009 cites W1995566406 @default.
• W2046369009 cites W2005523294 @default.
• W2046369009 cites W2005524286 @default.
• W2046369009 cites W2005915396 @default.
• W2046369009 cites W2012329749 @default.
• W2046369009 cites W2013774084 @default.
• W2046369009 cites W2017140565 @default.
• W2046369009 cites W2017605183 @default.
• W2046369009 cites W2022649266 @default.
• W2046369009 cites W2026927047 @default.
• W2046369009 cites W2031509959 @default.
• W2046369009 cites W2032494769 @default.
• W2046369009 cites W2035525109 @default.
• W2046369009 cites W2036164613 @default.
• W2046369009 cites W2039850455 @default.
• W2046369009 cites W2042626190 @default.
• W2046369009 cites W2050157569 @default.
• W2046369009 cites W2053315646 @default.
• W2046369009 cites W2061140050 @default.
• W2046369009 cites W2062264071 @default.
• W2046369009 cites W2063302591 @default.
• W2046369009 cites W2066867703 @default.
• W2046369009 cites W2067650446 @default.
• W2046369009 cites W2067709496 @default.
• W2046369009 cites W2082797190 @default.
• W2046369009 cites W2087748010 @default.
• W2046369009 cites W2089491627 @default.
• W2046369009 cites W2089967575 @default.
• W2046369009 cites W2090121937 @default.
• W2046369009 cites W2095029406 @default.
• W2046369009 cites W2097863314 @default.
• W2046369009 cites W2099675490 @default.
• W2046369009 cites W2102826458 @default.
• W2046369009 cites W2108617074 @default.
• W2046369009 cites W2120905250 @default.
• W2046369009 cites W2123774138 @default.
• W2046369009 cites W2128509983 @default.
• W2046369009 cites W2131799581 @default.
• W2046369009 cites W2141924291 @default.
• W2046369009 cites W2153734830 @default.
• W2046369009 cites W2154881226 @default.
• W2046369009 cites W2170262191 @default.
• W2046369009 cites W2173694857 @default.
• W2046369009 cites W2258625862 @default.
• W2046369009 cites W2267244966 @default.
• W2046369009 cites W2399788710 @default.
• W2046369009 cites W2408183683 @default.
• W2046369009 cites W2416825735 @default.
• W2046369009 cites W276203385 @default.
• W2046369009 cites W4239457256 @default.
• W2046369009 cites W4243487702 @default.
• W2046369009 cites W4290254878 @default.
• W2046369009 cites W4313333796 @default.
• W2046369009 cites W72427394 @default.
• W2046369009 doi "https://doi.org/10.1073/pnas.96.12.6896" @default.
• W2046369009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22013" @default.
• W2046369009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359810" @default.
• W2046369009 hasPublicationYear "1999" @default.
• W2046369009 type Work @default.
• W2046369009 sameAs 2046369009 @default.
• W2046369009 citedByCount "280" @default.
• W2046369009 countsByYear W20463690092012 @default.
• W2046369009 countsByYear W20463690092013 @default.
• W2046369009 countsByYear W20463690092014 @default.
• W2046369009 countsByYear W20463690092015 @default.
• W2046369009 countsByYear W20463690092016 @default.
• W2046369009 countsByYear W20463690092017 @default.
• W2046369009 countsByYear W20463690092018 @default.
• W2046369009 countsByYear W20463690092019 @default.
• W2046369009 countsByYear W20463690092020 @default.
• W2046369009 countsByYear W20463690092021 @default.

• next