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- W2046371833 abstract "The hypothalamus senses hormones and nutrients in order to regulate energy balance. In particular, detection of hypothalamic glucose levels has been shown to regulate both feeding behavior and peripheral glucose homeostasis, and impairment of this regulatory system is believed to be involved in the development of obesity and diabetes. Several data clearly demonstrate that glial cells are key elements in the perception of glucose, constituting with neurons a “glucose-sensing unit”. Characterization of this interplay between glia and neurons represents an exciting challenge, and will undoubtedly contribute to identify new candidates for therapeutic intervention. The purpose of this review is to summarize the current data that stress the importance of glia in central glucose-sensing. The nature of the glia-to-neuron signaling is discussed, with a special focus on the endozepine ODN, a potent anorexigenic peptide that is highly expressed in hypothalamic glia." @default.
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- W2046371833 date "2013-09-23" @default.
- W2046371833 modified "2023-09-25" @default.
- W2046371833 title "Hypothalamic Glucose-sensing: Role of Glia-to-Neuron Signaling" @default.
- W2046371833 doi "https://doi.org/10.1055/s-0033-1355357" @default.
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