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- W2046375040 abstract "The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials." @default.
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- W2046375040 date "2006-03-17" @default.
- W2046375040 modified "2023-10-16" @default.
- W2046375040 title "Structure of the MTIP–MyoA complex, a key component of the malaria parasite invasion motor" @default.
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- W2046375040 doi "https://doi.org/10.1073/pnas.0510907103" @default.
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