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• W2046376218 abstract "Fish oils have been widely reported as a useful supplement to reduce fasting blood triglyceride levels in individuals with hyperlipidemia. We performed an updated meta-analysis to quantitatively evaluate all the randomized trials of fish oils in hyperlipidemic subjects.We conducted a systematic literature search using several electronic databases supplemented by manual searches of published reference lists, review articles and conference abstracts. We included all placebo-controlled randomized trials of parallel design that evaluated any of the main blood lipid outcomes: total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol or triglycerides (TG). Data were pooled using DerSimonian-Laird's random effects model.The final analysis comprised of 47 studies in otherwise untreated subjects showed that taking fish oils (weighted average daily intake of 3.25 g of EPA and/or DHA) produced a clinically significant reduction of TG (-0.34 mmol/L, 95% CI: -0.41 to -0.27), no change in total cholesterol (-0.01 mmol/L, 95% CI: -0.03 to 0.01) and very slight increases in HDL (0.01 mmol/L, 95% CI: 0.00 to 0.02) and LDL cholesterol (0.06 mmol/L, 95% CI: 0.03 to 0.09). The reduction of TG correlated with both EPA+DHA intake and initial TG level.Fish oil supplementation produces a clinically significant dose-dependent reduction of fasting blood TG but not total, HDL or LDL cholesterol in hyperlipidemic subjects." @default.
• W2046376218 created "2016-06-24" @default.
• W2046376218 creator A5013940192 @default.
• W2046376218 creator A5031535978 @default.
• W2046376218 creator A5040967208 @default.
• W2046376218 creator A5066320861 @default.
• W2046376218 creator A5066552691 @default.
• W2046376218 date "2009-07-01" @default.
• W2046376218 modified "2023-10-16" @default.
• W2046376218 title "Benefits of fish oil supplementation in hyperlipidemia: a systematic review and meta-analysis" @default.
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• W2046376218 doi "https://doi.org/10.1016/j.ijcard.2008.03.092" @default.
• W2046376218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18774613" @default.
• W2046376218 hasPublicationYear "2009" @default.
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